儿童低磷酸酯酶症的口腔表现及酶替代疗法对口腔状况的影响：一系列临床病例
Dental manifestations of hypophosphatasia in children and the effects of enzyme replacement therapy on dental status: A series of clinical cases.
作者信息
Kiselnikova Larisa, Vislobokova Elena, Voinova Victoria
机构信息
Pediatric Dentistry Department A.I. Yevdokimov Moscow State University of Medicine and Dentistry Moscow Russia.
Department of Clinical Genetics Research and Clinical Institute for Pediatrics Named After Academician Yuri Veltischev Pirogov Russian National Research Medical University Moscow Russia.
出版信息
Clin Case Rep. 2020 Mar 13;8(5):911-918. doi: 10.1002/ccr3.2769. eCollection 2020 May.
The most frequent dental signs of hypophosphatasia in children are premature loss of primary teeth, decrease in height of alveolar bone, and malocclusions. Enzyme replacement therapy with Asfotase alfa might be associated with stabilization of dental status.
儿童低磷酸酯酶症最常见的牙齿症状是乳牙过早脱落、牙槽骨高度降低和咬合不正。使用阿法骨化醇酶进行酶替代疗法可能与牙齿状况的稳定有关。
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