Department of Vascular Surgery, The Second People's Hospital of Yunnan Province, Kunming, Yunnan, 650021, China.
Department of Vascular Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China.
J Environ Pathol Toxicol Oncol. 2020;39(1):61-75. doi: 10.1615/JEnvironPatholToxicolOncol.2020031478.
Atherosclerosis is a multifactorial disease that develops and progresses in the arterial wall in response to a variety of stimuli. Among various other stimuli, hyperlipidemia is an extremely important factor that is correlated with the development of atherosclerosis. Lemon and citrus fruits contain various bioactive flavonoids, such as eriocitrin, that prevent obesity and related metabolic diseases. Therefore we concentrated on eriocitrin, a potent flavonoid with numerous therapeutic properties, particularly its beneficial lipid-lowering action in rats subjected to high fat diet. The anti-atherosclerotic efficacy of eriocitrin was assessed in rats administered a diet rich in fat. Wistar rats were divided into five groups consisting of six animals in all groups. Group I served the control, Group II was fed a high-fat diet (HFD), and the third and fourth groups were fed an HFD supplemented with varying doses of eriocitrin, and the last group was administered simvastatin for the last 30 days. Body weight, organ weight, lipid and lipoprotein parameters, cardiac and inflammatory markers, and histological examination were evaluated in animals induced with an HFD. Eriocitrin displayed a significant anti-atherosclerotic action by lowering the body weight, organ weight, reduction in lipid content, cardiac and inflammatory markers, myocardial changes confirmed by histopathology, malondialdehyde and increased antioxidant enzyme activities, nitric oxide, as well as 6-keto-PGF1α and high-density lipoprotein levels in rats fed an HFD. The findings of the experiment suggest that the anti-atherosclerotic action of eriocitrin was due to its modulatory activity in lipid metabolism. Considering the overall results of the study it can be validated that a use of flavonoid eriocitrin might be beneficial in altering HFD-induced alterations in atherosclerotic rats.
动脉粥样硬化是一种多因素疾病，它在动脉壁中发展和进展，以响应各种刺激。在各种其他刺激中，高脂血症是一个极其重要的因素，与动脉粥样硬化的发展相关。柠檬和柑橘类水果含有各种生物活性类黄酮，如桔皮苷，可预防肥胖和相关代谢疾病。因此，我们专注于桔皮苷，一种具有多种治疗特性的强效类黄酮，特别是其在高脂肪饮食大鼠中有益的降血脂作用。在给予高脂肪饮食的大鼠中评估了桔皮苷的抗动脉粥样硬化功效。Wistar 大鼠分为五组，每组六只动物。第 I 组为对照组，第 II 组给予高脂肪饮食（HFD），第 3 组和第 4 组给予 HFD 补充不同剂量的桔皮苷，最后一组在最后 30 天给予辛伐他汀。在给予 HFD 的动物中评估了体重、器官重量、脂质和脂蛋白参数、心脏和炎症标志物以及组织学检查。桔皮苷通过降低体重、器官重量、降低脂质含量、心脏和炎症标志物、组织病理学证实的心肌变化、丙二醛和增加抗氧化酶活性、一氧化氮以及 6-酮-PGF1α 和高密度脂蛋白水平，显示出显著的抗动脉粥样硬化作用。在给予高脂肪饮食的大鼠中。实验结果表明，桔皮苷的抗动脉粥样硬化作用是由于其对脂质代谢的调节活性。考虑到研究的整体结果，可以验证使用类黄酮桔皮苷可能有益于改变动脉粥样硬化大鼠中 HFD 诱导的变化。
