Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, People's Republic of China.
School of Pharmacy, Linyi University, Linyi 276000, People's Republic of China.
J Nat Prod. 2020 Jun 26;83(6):1766-1777. doi: 10.1021/acs.jnatprod.9b00895. Epub 2020 Jun 1.
Fourteen new terpenoids plagicosins A-N (-), including seven sesquiterpenoids (-) consisting of six -bicyclogermacrenes and one -2,3--aromadendrane, as well as seven diterpenoids (-) comprising five fusicoccanes, a eunicellane, and a rare gersemiane, were isolated from the Chinese liverwort Mitt. The structures of these terpenoids were determined on the basis of comprehensive analysis of MS and NMR spectroscopic data coupled with electronic circular dichroism (ECD) and coupling constant calculations. Plagicosin F () displayed potent antivirulence activity through inhibiting the hyphal morphogenesis, adhesion, and biofilm formation of . The genes related to hyphal formation were regulated by .
十四种新的倍半萜类化合物 plagicosins A-N（-），包括 7 种倍半萜类化合物（-），由 6 种双环 germacrenes 和 1 种 2,3--aromadendrane 组成，以及 7 种二萜类化合物（-），包括 5 种 fusicoccanes、一个 eunicellane 和一个罕见的 gersemiane，从中国肝蕨 Mitt 中分离出来。这些萜类化合物的结构是根据 MS 和 NMR 光谱数据的综合分析以及电子圆二色性（ECD）和耦合常数计算来确定的。Plagicosin F（-）通过抑制菌丝形态发生、粘附和生物膜形成，显示出很强的抗病毒毒力活性。与菌丝形成相关的基因受调控。
