Terpenoids from the Liverwort and Their Antivirulence Activity against .

Fourteen new terpenoids plagicosins A-N (-), including seven sesquiterpenoids (-) consisting of six -bicyclogermacrenes and one -2,3--aromadendrane, as well as seven diterpenoids (-) comprising five fusicoccanes, a eunicellane, and a rare gersemiane, were isolated from the Chinese liverwort Mitt. The structures of these terpenoids were determined on the basis of comprehensive analysis of MS and NMR spectroscopic data coupled with electronic circular dichroism (ECD) and coupling constant calculations. Plagicosin F () displayed potent antivirulence activity through inhibiting the hyphal morphogenesis, adhesion, and biofilm formation of . The genes related to hyphal formation were regulated by .