磷酸甘油酸激酶 1（PGK1）在癌症中的作用：诊断和治疗的有希望的靶点。

Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target for diagnosis and therapy.

机构信息

Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, PR China.; College of Bioscience and Technology, Weifang Medical University, Weifang, Shandong Province, PR China.

Department of Reproductive Medicine, Affiliated Hospital of Weifang Medical University, Weifang, Shandong Province, PR China..

出版信息

Life Sci. 2020 Sep 1;256:117863. doi: 10.1016/j.lfs.2020.117863. Epub 2020 May 30.

DOI:10.1016/j.lfs.2020.117863

PMID:32479953

Abstract

Phosphoglycerate kinase 1 (PGK1) is the first critical enzyme to produce ATP in the glycolytic pathway. PGK1 is not only a metabolic enzyme but also a protein kinase, which mediates the tumor growth, migration and invasion through phosphorylation some important substrates. Moreover, PGK1 is associated with poor treatment and prognosis of cancers. This manuscript reviews the structure, functions, post-translational modifications (PTMs) of PGK1 and its relationship with tumors, which demonstrates that PGK1 has indispensable value in the tumor progression. The current review highlights the important role of PGK1 in anticancer treatments.

摘要

磷酸甘油酸激酶 1（PGK1）是糖酵解途径中产生 ATP 的第一个关键酶。PGK1 不仅是一种代谢酶，还是一种蛋白激酶，通过磷酸化一些重要底物来介导肿瘤的生长、迁移和侵袭。此外，PGK1 与癌症的不良治疗和预后有关。本文综述了 PGK1 的结构、功能、翻译后修饰（PTMs）及其与肿瘤的关系，表明 PGK1 在肿瘤进展中具有不可或缺的价值。本综述强调了 PGK1 在抗癌治疗中的重要作用。