Mizushima H, Matsumoto K, Ryu H, Usami S, Doi H, Kuwasawa J, Matsui S
Department of Neurosurgery, Showa University School of Medicine, Tokyo, Japan.
No To Shinkei. 1988 Dec;40(12):1157-62.
Thymoma with extrathoracic metastasis is very rare, especially to the central nervous system. As far as we know, this is the 15th reported case of cerebral metastasis from malignant thymoma. The prognosis is very poor and almost all of them die in one to one and half years. We have experienced such a case, who is 56 years old man, presenting Gerstmann's syndrome and right-hemiparesis 8 months later after thoracotomy for removal of thymoma. At the admission time in this hospital, CT findings proved the tumor in the left temporoparietal area, left ventricle deformity and slight midline shift to right side. The average of CT density in the low density area was 20. Peripheral region of the tumor was enhanced by contrast CT. Left carotid angiography showed the ACA shift to the right side and abnormal vascularity of peripheral branches of angular artery (arterial phase) and also tumor strain in late artery (arterial phase) and also tumor strain in late arterial phase. Brain scintigram revealed accumulation in the left parietal region. The rt-hemiparesis was rapidly going to be rt-hemiplegia. Therefore, we have performed needle puncture to prevent rt-hemiplegia at the first time. In the course of needle puncture, 90 ml of dark and red fluid was gained at 3.0 cm depth from the cerebral surface. Immediately, the above two symptoms have improved remarkably. Post operative CT showed the reduction of tumor and improvement of the midline shift. The radical operation have been done 2 days after the needle puncture. The tumor was elastic-soft and hemorrhagic and appeared dark-red.(ABSTRACT TRUNCATED AT 250 WORDS)
胸腺瘤伴胸外转移非常罕见,尤其是转移至中枢神经系统。据我们所知,这是第15例报道的恶性胸腺瘤脑转移病例。预后非常差,几乎所有患者在1至1年半内死亡。我们曾遇到这样一例患者,是一名56岁男性,在因切除胸腺瘤行开胸手术后8个月出现格斯特曼综合征和右侧偏瘫。在本院入院时,CT检查发现左侧颞顶叶有肿瘤,左心室变形,中线轻度向右移位。低密度区CT密度平均值为20。肿瘤周边区域在增强CT时有强化。左侧颈动脉血管造影显示大脑前动脉向右移位,角动脉周边分支血管异常(动脉期),动脉晚期也有肿瘤压迫(动脉期)。脑闪烁造影显示左侧顶叶区域有放射性聚集。右侧偏瘫迅速发展为右侧全瘫。因此,我们首次进行了穿刺以预防右侧全瘫。穿刺过程中,在距脑表面3.0厘米深处抽出90毫升暗红色液体。随即,上述两种症状明显改善。术后CT显示肿瘤缩小,中线移位改善。穿刺后2天进行了根治性手术。肿瘤质地软且有弹性,有出血,呈暗红色。(摘要截选至250字)