Rao V S, Menezes A M, Gadelha M G, Fonteles M C
Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Fortaleza, Brasil.
Braz J Med Biol Res. 1988;21(5):1023-5.
The influence of the calcium-entry blockers, verapamil, nifedipine and diltiazem on hydrochlorothiazide-induced diuresis was determined in hydrated conscious rats. Nifedipine significantly inhibited hydrochlorothiazide-induced 5-h excreted urine volume and urinary sodium with little effect on potassium excretion. Both verapamil and diltiazem significantly enhanced urinary sodium excretion with no effect on either urine volume or potassium excretion. These results are of interest in view of the current use of nifedipine as an anti-hypertensive agent, alone or in combination with a thiazide diuretic.
在水合清醒大鼠中测定了钙通道阻滞剂维拉帕米、硝苯地平和地尔硫䓬对氢氯噻嗪诱导利尿的影响。硝苯地平显著抑制氢氯噻嗪诱导的5小时尿量和尿钠排泄，对钾排泄影响较小。维拉帕米和地尔硫䓬均显著增强尿钠排泄，对尿量或钾排泄均无影响。鉴于目前硝苯地平单独或与噻嗪类利尿剂联合用作抗高血压药物，这些结果值得关注。
