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[针对携带BRCA基因突变的双侧预防性乳房切除术采用植入物进行乳房重建的新手术策略]

[New surgical strategy in breast reconstruction with implants for bilateral prophylactic mastectomies with BRCA gene mutation].

作者信息

Deveaux C, Calibre C, Duquennoy-Martinot V, Guerreschi P, Dumont A

机构信息

Service de chirurgie plastique, reconstructrice et esthétique et centre de traitement des Brûlés, hôpital Roger-Salengro, centre hospitalier et universitaire de Lille, avenue Émile-Laine, 59037 Lille cedex, France.

Service de chirurgie plastique, reconstructrice et esthétique et centre de traitement des Brûlés, hôpital Roger-Salengro, centre hospitalier et universitaire de Lille, avenue Émile-Laine, 59037 Lille cedex, France.

出版信息

Ann Chir Plast Esthet. 2020 Jul;65(4):284-293. doi: 10.1016/j.anplas.2020.05.004. Epub 2020 May 29.

DOI:10.1016/j.anplas.2020.05.004
PMID:32482352
Abstract

BACKGROUND

For the past decades, number of prophylactic bilateral mastectomies using reconstruction with implants increases. We describe a new surgical strategy and analyse its safety and feasability.

METHOD

It is a retrospective, descriptive and monocentric study. The first step of surgery consisted in obteining a peri-prosthetic capsule with implants and if there was a mammary hypertrophy and/or ptosis, it was corrected at the same time. The second step of surgery was the nipple-sparing mastectomy with change of implants for bigger ones. Third step consisted in a lipofilling.

RESULTS

Seven patients were included. 6 women had a BRCA1 gene mutation. Mean age was 35.6 year-old [29.6; 41.6], mean BMI was 23.8kg/m [20.6; 27], mean chest circumference was 93.7cm [87.4; 100], mean cup was C- [B-; D-]. 4 women had mammary hypertrophy and/or ptosis. Mean number of procedure per woman was 3.6 [2.5; 4.7]. Mean volume of implants used at the first step was 248.6ml [211.3; 285.9]. The second step was performed mean 33.9 weeks [22.3; 45.5] later. Mean increase of implants volume was 120ml [80.4; 159.6]. 4 patients had complications including 1 who had implant exposure. Six patients had lipofilling of mean volume per breast of 175ml [116; 234].

CONCLUSION

This new strategy could decrease complication rate, improve aesthetic outcome and decrease psychological impact of surgery.

摘要

背景

在过去几十年中,采用植入物重建的预防性双侧乳房切除术的数量有所增加。我们描述了一种新的手术策略,并分析其安全性和可行性。

方法

这是一项回顾性、描述性的单中心研究。手术的第一步是用植入物获得假体周围包膜,如果存在乳腺肥大和/或乳房下垂,则同时进行矫正。手术的第二步是保留乳头的乳房切除术,更换为更大的植入物。第三步是脂肪填充。

结果

纳入7例患者。6名女性存在BRCA1基因突变。平均年龄为35.6岁[29.6;41.6],平均体重指数为23.8kg/m²[20.6;27],平均胸围为93.7cm[87.4;100],平均罩杯为C-[B-;D-]。4名女性存在乳腺肥大和/或乳房下垂。每位女性的平均手术次数为3.6次[2.5;4.7]。第一步使用的植入物平均体积为248.6ml[211.3;285.9]。第二步平均在33.9周[22.3;45.5]后进行。植入物体积平均增加120ml[80.4;159.6]。4例患者出现并发症,其中1例发生植入物外露。6例患者进行了脂肪填充,每侧乳房的平均填充量为175ml[116;234]。

结论

这种新策略可以降低并发症发生率,改善美学效果,并减少手术对心理的影响。

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