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托珠单抗：COVID-19 中细胞因子风暴综合征治疗的一种治疗选择。

Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19.

机构信息

Department of Biotechnology, School of Life Science and Biotechnology, Adamas University, Kolkata, West Bengal, India.

Institute for Skeletal Aging and Orthopedic Surgery, Hallym University-Chuncheon Sacred Heart Hospital, Chuncheon-si, Gangwon-do, South Korea.

出版信息

Arch Med Res. 2020 Aug;51(6):595-597. doi: 10.1016/j.arcmed.2020.05.009. Epub 2020 May 21.

DOI:10.1016/j.arcmed.2020.05.009
PMID:32482373
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7241374/
Abstract

Presently, we need more therapeutic molecules for this COVID-19 outbreak. The severity and mortality of the disease is associated with a high level of release of cytokine in the patients which is known as CRS (cytokine release syndrome) or cytokine storm syndrome. IL-6 is a type of pro-inflammatory cytokine which release in the severe COVID-19 patients. This cytokine initiates CRS the JAK-STAT or MAPK/NF-κB-IL-6 pathway. Tocilizumab, a humanized monoclonal antibody, is designed to bind both mIL-6R (membrane bound receptor for IL-6) and sIL-6R (soluble receptor for IL-6) and inhibit the JAK-STAT or MAPK/NF-κB-IL-6 signaling pathway. It finally stops the cytokine storm syndrome. However, we need to understand that how tocilizumab is bound with mIL-6R or sIL-6R. Similarly, we also need to understand more about the real molecular mechanism of activity of tocilizumab.

摘要

目前，我们需要更多针对这种 COVID-19 爆发的治疗性分子。这种疾病的严重程度和死亡率与患者体内高水平的细胞因子释放有关，这被称为 CRS（细胞因子释放综合征）或细胞因子风暴综合征。IL-6 是一种促炎细胞因子，在严重的 COVID-19 患者中释放。这种细胞因子引发 CRS，即 JAK-STAT 或 MAPK/NF-κB-IL-6 途径。托珠单抗是一种人源化单克隆抗体，旨在结合 mIL-6R（IL-6 的膜结合受体）和 sIL-6R（IL-6 的可溶性受体），并抑制 JAK-STAT 或 MAPK/NF-κB-IL-6 信号通路。它最终阻止了细胞因子风暴综合征。然而，我们需要了解托珠单抗如何与 mIL-6R 或 sIL-6R 结合。同样，我们也需要更多地了解托珠单抗的实际分子作用机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e4/7241374/5688dfe9c9e5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e4/7241374/5688dfe9c9e5/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45e4/7241374/5688dfe9c9e5/gr1_lrg.jpg

相似文献

[1]
Tocilizumab: A Therapeutic Option for the Treatment of Cytokine Storm Syndrome in COVID-19.

Arch Med Res. 2020-5-21

[2]
Cytokine release syndrome in severe COVID-19: interleukin-6 receptor antagonist tocilizumab may be the key to reduce mortality.

Int J Antimicrob Agents. 2020-3-29

[3]
COVID-19: Consider IL-6 receptor antagonist for the therapy of cytokine storm syndrome in SARS-CoV-2 infected patients.

J Med Virol. 2020-6-19

[4]
Treat 2019 novel coronavirus (COVID-19) with IL-6 inhibitor: Are we already that far?

Drug Discov Ther. 2020

[5]
IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome.

Proc Natl Acad Sci U S A. 2020-8-21

[6]
Clinical characteristics and predictors of survival in adults with coronavirus disease 2019 receiving tocilizumab.

J Autoimmun. 2020-7-3

[7]
The COVID-19 Cytokine Storm; What We Know So Far.

Front Immunol. 2020-6-16

[8]
Potential Treatments for COVID-19 Related Cytokine Storm - Beyond Corticosteroids.

Front Immunol. 2020-6-16

[9]
Amelioration of COVID-19-related cytokine storm syndrome: parallels to chimeric antigen receptor-T cell cytokine release syndrome.

Br J Haematol. 2020-8

[10]
Rational Use of Tocilizumab in the Treatment of Novel Coronavirus Pneumonia.

Clin Drug Investig. 2020-6

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[3]
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[4]
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Arch Acad Emerg Med. 2024-5-9

[5]
SARS-CoV-2 Omicron Spike shows strong binding affinity and favourable interaction landscape with the TLR4/MD2 compared to other variants.

J Genet Eng Biotechnol. 2024-3

[6]
A brief overview of SARS-CoV-2 infection and its management strategies: a recent update.

Mol Cell Biochem. 2024-9

[7]
Tocilizumab-coated solid lipid nanoparticles loaded with cannabidiol as a novel drug delivery strategy for treating COVID-19: A review.

Front Immunol. 2023

[8]
SARS-CoV-2 Vaccines, Vaccine Development Technologies, and Significant Efforts in Vaccine Development during the Pandemic: The Lessons Learned Might Help to Fight against the Next Pandemic.

Vaccines (Basel). 2023-3-17

[9]
The role of HLA genotypes in understanding the pathogenesis of severe COVID-19.

Egypt J Med Hum Genet. 2023

[10]
Pathfinder-Driven Chemical Space Exploration and Multiparameter Optimization in Tandem with Glide/IFD and QSAR-Based Active Learning Approach to Prioritize Design Ideas for FEP+ Calculations of SARS-CoV-2 PL Inhibitors.

Molecules. 2022-12-5

本文引用的文献

[1]
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