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感染 COVID-19 和其他冠状病毒后的神经系统并发症。

Nervous system involvement after infection with COVID-19 and other coronaviruses.

机构信息

Department of Anesthesiology and Perioperative Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China; Department of Cardiology, The Third Affiliated Hospital of Soochow University, Changzhou 213003, China.

Department of Anesthesiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430030, China.

出版信息

Brain Behav Immun. 2020 Jul;87:18-22. doi: 10.1016/j.bbi.2020.03.031. Epub 2020 Mar 30.

Abstract

Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.

摘要

病毒感染对神经系统功能有不利影响,甚至导致严重的神经损伤。就在最近,冠状病毒(CoV),特别是严重急性呼吸综合征冠状病毒 2(SARS-CoV-2),表现出嗜神经性,并可能导致神经系统疾病。据报道,CoV 可在大脑或脑脊液中被发现。这些神经侵袭性病毒的发病机制尚不完全清楚,因此,探讨 CoV 感染对神经系统的影响非常重要。在这里,我们综述了 CoV 感染引起的神经系统并发症的研究,以及对神经系统损伤的可能机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/478e/7146689/3d610bf422a7/gr1_lrg.jpg

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