化疗和肿瘤演进塑造了胰腺癌切除术后的复发模式。
Chemotherapy and Tumor Evolution Shape Pancreatic Cancer Recurrence after Resection.
机构信息
Department of Surgery, University of Michigan, Ann Arbor, Michigan.
Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan.
出版信息
Cancer Discov. 2020 Jun;10(6):762-764. doi: 10.1158/2159-8290.CD-20-0359.
Most patients with pancreatic cancer who undergo curative resection and systemic chemotherapy still relapse with local or systemic recurrence. In this issue, Sakamoto and colleagues use advanced genomic tools to investigate the evolutionary origins of pancreatic cancer recurrence and discover an increased mutational burden that might be promoted by therapeutic intervention and might provide an opportunity for therapeutic intervention..
大多数接受根治性切除术和全身化疗的胰腺癌患者仍会出现局部或全身复发。在本期杂志中，Sakamoto 及其同事利用先进的基因组工具来研究胰腺癌复发的进化起源，并发现了可能由治疗干预促进的增加的突变负担，这可能为治疗干预提供机会。
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