Department of Internal Medicine, Pulmonary Section, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Thorax. 2020 Sep;75(9):808-811. doi: 10.1136/thoraxjnl-2019-214496. Epub 2020 Jun 1.
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) reportedly promotes, or conversely, resolves inflammation in asthma. In this study of TRAIL and cell receptors in sputum, bronchoalveolar lavage and biopsy from subjects in the Severe Asthma Research Program at Wake Forest, the high TRAIL group had significant increases in all leucocytes, and was associated with increased type 1, type 2 and type 17 cytokines, but not type 9 interleukin 9. Two variants at loci in the TRAIL gene were associated with higher sputum levels of TRAIL. Increased TRAIL decoy receptor R3/DcR1 was observed on sputum leucocytes compared with death receptor R1/DR4, suggesting reduced apoptosis and prolonged cellular inflammation.
肿瘤坏死因子相关凋亡诱导配体（TRAIL）据报道可促进或相反地缓解哮喘中的炎症。在这项来自维克森林大学严重哮喘研究计划（Severe Asthma Research Program）中痰液、支气管肺泡灌洗液和活检中 TRAIL 和细胞受体的研究中，高 TRAIL 组的所有白细胞均显著增加，与 1 型、2 型和 17 型细胞因子增加相关，但与 9 型白细胞介素 9 无关。TRAIL 基因中的两个位点变异与 TRAIL 水平升高相关。与死亡受体 R1/DR4 相比，在痰液白细胞上观察到 TRAIL 诱饵受体 R3/DcR1 增加，表明凋亡减少和细胞炎症持续时间延长。
