Karyotype evolution in the bone marrow of a patient with Fanconi anemia: breakpoints in clonal anomalies of this disease.
作者信息
Huret J L, Tanzer J, Guilhot F, Frocrain-Herchkovitch C, Savage J R
机构信息
Departement de Hématologie et Oncologie Médicale, Hôpital Jean Bernard, Poitiers, France.
出版信息
Cytogenet Cell Genet. 1988;48(4):224-7. doi: 10.1159/000132633.
PMID:3248378
Abstract
A 21-year-old Fanconi anemia patient developed refractory anemia. Laboratory studies revealed a transitory increased platelet count and a typical del(5q). Bone marrow karyotyping showed a -6, +der(6)t(1;6)(q12;p25) rearrangement and, two years later, a mosaic -6, +der(6),t(1:6)(q12;p25)/-2, +der 2), t(1;2)(q12;q37) constitution. The chromosome mechanism operating in this patient is discussed.
摘要
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