掌腱膜挛缩症治疗中外侧松解术和胶原酶 clostridium histolyticum 的疗效和局限性：荟萃分析。
The efficacies and limitations of fasciectomy and collagenase clostridium histolyticum in Dupuytren's contracture management: A meta-analysis.
机构信息
Department of Orthopedics (Division of Plastic and Hand Surgery), The Second Affiliated Hospital and YuYing Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China.
出版信息
J Orthop Surg (Hong Kong). 2020 Jan-Apr;28(2):2309499020921747. doi: 10.1177/2309499020921747.
BACKGROUND
We intend to assess the efficacies and limitations of collagenase clostridium histolyticum (CCH) and fasciectomy in treating Dupuytren's contracture, and the associated complications and rate of recurrences aiming to present a treatment algorithm.
METHODS
A literature search within the PubMed, Web of Sciences, Cochrane Library, and EMBASE databases was performed using the combined key words 'Dupuytren, palmar aponeurosis contracture, collagenase clostridium histolyticum and fasciectomy', including all possible studies with a set of predefined inclusion and exclusion criteria.
RESULTS
Thirty studies were assessed for eligibility from 215 identified records. Seventeen publications satisfied the inclusion criteria including 2142 joints in 1784 patients. The mean follow-up time was 18.0 months (3-60).
CONCLUSION
Acceptable contractures release was obtained in both techniques. Severe complications associated with fasciectomy outrank those of CCH, whereas the low rate of recurrence favors the fasciectomy technique.
背景
我们旨在评估胶原酶克氏梭菌（CCH）和筋膜切除术治疗掌腱膜挛缩的疗效和局限性，以及相关并发症和复发率，旨在提出一种治疗方案。
方法
在 PubMed、Web of Sciences、Cochrane 图书馆和 EMBASE 数据库中，使用“Dupuytren、掌腱膜挛缩、胶原酶克氏梭菌和筋膜切除术”的组合关键词进行文献检索，包括所有符合一套预定纳入和排除标准的可能研究。
结果
从 215 篇已确定的记录中评估了 30 项研究的合格性，包括 1784 名患者的 2142 个关节。平均随访时间为 18.0 个月（3-60）。
结论
两种技术均能获得可接受的挛缩释放。筋膜切除术相关的严重并发症多于 CCH，而 CCH 复发率较低。
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