单光子发射 CT 与螺旋 CT 联合用于骨转移的早期检测和定位：综述。

Single-photon Emission CT Combined with Spiral CT for Early Detection and Localization of Bone Metastasis: A Review.

机构信息

Department of Nuclear Medicine, University of Health Sciences, Ankara Numune Training and Research Hospital, Ankara, Turkey.

Department of Nuclear Medicine, Sabuncuoglu Serefeddin Training and Research Hospital, University of Amasya, Amasya, Turkey.

出版信息

Curr Med Imaging. 2020;16(5):507-512. doi: 10.2174/1573405615666181224143010.

DOI:10.2174/1573405615666181224143010

PMID:32484085

Abstract

BACKGROUND

Bone metastasis is common in cancer. Evaluating the metastatic status in cancer is of utmost importance in order to provide the best patient's management.

DISCUSSION

Bone scintigraphy is widely used for evaluation of bone metastasis. It has high sensitivity with limited specificity. Planar bone scintigraphy has been shown to have increased radiotracer uptake without accurate anatomic localization and characterization. Hybrid Single-Photon Emission Computed Tomography/Computerized Tomography (SPECT/CT) system has been developed by combination of SPECT and CT. Accurate lesion localization and discrimination of equivocal bone lesions is an advantage in this hybrid technique. It improves diagnostic accuracy by differentiation of benign bone lesions from malignant ones due to their morphological changes. So, SPECT/CT improves the specificity of bone scintigraphy leading to better outcomes in diagnosis and treatment outcomes of bone metastatic cancer patients.

CONCLUSION

In here, we discussed the prognostic value of bone scintigraphy and SPECT/CT in bone metastasis with our clinical experience and review of the literature.

摘要

背景

癌症患者常发生骨转移。为了提供最佳的患者管理，评估癌症的转移状态至关重要。

讨论

骨闪烁扫描术广泛用于评估骨转移。它具有较高的灵敏度，特异性有限。平面骨闪烁扫描术显示放射性示踪剂摄取增加，但无法准确进行解剖定位和特征描述。单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）混合系统通过 SPECT 和 CT 的组合而开发。该混合技术的优势在于准确的病变定位和疑似骨病变的鉴别。由于其形态学变化，它通过区分良性骨病变和恶性骨病变来提高诊断准确性。因此，SPECT/CT 提高了骨闪烁扫描术的特异性，从而改善了骨转移癌患者的诊断和治疗效果。