Environmental Health Sciences Program, Department of Health Education and Promotion, College of Health and Human Performance, East Carolina University, Greenville, NC.
Department of Public Health, Brody School of Medicine, East Carolina University, Greenville, NC.
J Med Entomol. 2020 Nov 13;57(6):1992-1996. doi: 10.1093/jme/tjaa101.
Aedes aegypti (L.) is the primary vector of Zika, dengue, yellow fever, and chikungunya viruses. Insecticides used in mosquito control can help prevent the spread of vector-borne diseases. However, it is essential to determine insecticide resistance (IR) status before control measures are undertaken. Only the most effective insecticides should be used to avoid ineffective control and/or promotion of IR. Pyrethroids and organophosphates are the most commonly used insecticides for mosquito control. Here, the efficacy of two active ingredients (AIs; permethrin [pyrethroid], chlorpyrifos [organophosphate]), two formulated products (FPs; Biomist [AI: permethrin]) and (Mosquitomist [AI: chlorpyrifos]), and three synergists (piperonyl butoxide, diethyl maleate, S-S-S-tributyl phosphorotrithioate) was evaluated in two Ae. aegypti colonies (pyrethroid resistant and susceptible). Mosquitomist was most effective against the pyrethroid-resistant colony (100% mortality at diagnostic time). Pre-exposure to synergists did not increase the efficacy of AIs against the pyrethroid-resistant colony. Further research is needed to discover how synergists may affect the efficacy of insecticides when used on pyrethroid-resistant mosquitoes.
埃及伊蚊（L.）是寨卡、登革热、黄热病和基孔肯雅热病毒的主要传播媒介。用于控制蚊子的杀虫剂有助于预防媒介传播疾病的传播。然而，在采取控制措施之前，确定杀虫剂抗性（IR）状况至关重要。只有最有效的杀虫剂才应使用，以避免无效控制和/或促进 IR。拟除虫菊酯和有机磷是用于控制蚊子的最常用杀虫剂。在这里，评估了两种活性成分（AIs；氯菊酯[拟除虫菊酯]、毒死蜱[有机磷]）、两种配制品（Biomist [AI：氯菊酯]）和（Mosquitomist [AI：毒死蜱]）以及三种增效剂（增效醚、顺丁烯二酸二乙酯、S-S-S-三丁基磷硫代酸酯）在两个埃及伊蚊种群（对拟除虫菊酯具有抗性和敏感）中的功效。Mosquitomist 对拟除虫菊酯抗性种群最有效（在诊断时间达到 100%死亡率）。增效剂预先暴露并没有增加 AIs 对拟除虫菊酯抗性种群的功效。需要进一步研究以发现增效剂在用于对拟除虫菊酯具有抗性的蚊子时如何影响杀虫剂的功效。
