Yikilmaz A S, Akinci S, Bakanay S M, Dilek I
Bratisl Lek Listy. 2020;121(6):422-427. doi: 10.4149/BLL_2020_068.
Myelodysplastic syndromes (MDS) include various hematologic abnormalities characterized by chronic cytopenia due to disruption in cellular differentiation. This study aims to evaluate the prognostic value of PLR in patients with MDS.
Clinical-laboratory findings and the results of bone marrow biopsies of MDS patients before treatment were recorded. p value of <0.05 was considered statistically significant. SPSS version 20.0 was used for statistical analysis.
The study included 62 patients with median follow-up time of 62.8±4.5 months and median age of 68.5 years. In 13 patients, acute leukemia was transformed. In these subjects, a PLR cut-off level of 46 was established for mortality (p=0.015). We found a significant relationship between PLR and multilineage series with the presence of dysplasia (p=0.017). The survival analysis showed a decreased survival in cases with dysplasia in two and/or more series, transformation into acute leukemia, and thrombocytopenia.
Our study demonstrated that there was a relationship between PLR and MDS with multilineage dysplasia (mld-MDS). PLR is investigated as an inflammatory finding in various hematologic malignancies. Further studies investigating the value of PLR in MDS are needed to determine whether PLR may be a marker of bone marrow dysplasia grading (Tab. 2, Fig. 4, Ref. 32).
骨髓增生异常综合征（MDS）包括各种血液学异常，其特征为细胞分化紊乱导致的慢性血细胞减少。本研究旨在评估血小板与淋巴细胞比值（PLR）在MDS患者中的预后价值。
记录MDS患者治疗前的临床实验室检查结果及骨髓活检结果。p值<0.05被认为具有统计学意义。使用SPSS 20.0版进行统计分析。
该研究纳入62例患者，中位随访时间为62.8±4.5个月，中位年龄为68.5岁。13例患者发生急性白血病转化。在这些患者中，确定PLR截止水平为46时与死亡率相关（p=0.015）。我们发现PLR与存在发育异常的多系系列之间存在显著关系（p=0.017）。生存分析显示，两个及以上系列存在发育异常、转化为急性白血病和血小板减少的患者生存率降低。
我们的研究表明，PLR与多系发育异常的骨髓增生异常综合征（mld-MDS）之间存在关联。PLR在各种血液系统恶性肿瘤中作为一种炎症表现进行研究。需要进一步研究PLR在MDS中的价值，以确定PLR是否可能是骨髓发育异常分级的标志物（表2，图4，参考文献32）。
