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Blood Adv. 2020 Jun 9;4(11):2404-2408. doi: 10.1182/bloodadvances.2019001316.
2
Interference in specialized coagulation assays affecting the protein C pathway: Effects of marked haemolysis, hyperbilirubinaemia and lipaemia on chromogenic and clotting tests on two coagulation platforms.干扰影响蛋白 C 途径的特定凝血检测：显著溶血、高胆红素血症和脂血对两种凝血平台上发色和凝固检测的影响。
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3
Laboratory diagnosis of resistance to activated protein C (APC-resistance).活化蛋白C抵抗（APC抵抗）的实验室诊断
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Another protein S functional assay is sensitive to resistance to activated protein C.另一种蛋白S功能测定对活化蛋白C抵抗敏感。
Thromb Haemost. 1994 Oct;72(4):648.
5
Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report.高密度脂蛋白抗凝特性的重新评估——简要报告
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Activated protein C: a promising drug with multiple effects?活化蛋白C：一种具有多种作用的有前景的药物？
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The protein C pathway in inflammatory bowel disease: the missing link between inflammation and coagulation.炎症性肠病中的蛋白C途径：炎症与凝血之间缺失的环节。
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Modification of the cytoprotective protein C pathway during Dengue virus infection of human endothelial vascular cells.登革病毒感染人内皮血管细胞期间细胞保护蛋白C途径的改变。
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10
Plasma resistance to activated protein C regulates the activation of coagulation induced by thrombolysis in patients with ischaemic heart disease.血浆对活化蛋白C的抵抗作用调节缺血性心脏病患者溶栓诱导的凝血激活。
Heart. 1997 Feb;77(2):122-7. doi: 10.1136/hrt.77.2.122.

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Combined with dynamic serum proteomics and clinical follow-up to screen the serum proteins to promote the healing of diabetic foot ulcer.结合动态血清蛋白质组学和临床随访筛选促进糖尿病足溃疡愈合的血清蛋白。
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Do Circulating Histones Represent the Missing Link among COVID-19 Infection and Multiorgan Injuries, Microvascular Coagulopathy and Systemic Hyperinflammation?循环组蛋白是新冠病毒感染与多器官损伤、微血管凝血病和全身炎症之间缺失的环节吗？
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APOA1: a Protein with Multiple Therapeutic Functions.载脂蛋白 A1：具有多种治疗功能的蛋白质。
Curr Atheroscler Rep. 2021 Feb 16;23(3):11. doi: 10.1007/s11883-021-00906-7.

本文引用的文献

1
Cell biology of activated protein C.活化蛋白 C 的细胞生物学。
Curr Opin Hematol. 2019 Jan;26(1):41-50. doi: 10.1097/MOH.0000000000000473.
2
PAR1 biased signaling is required for activated protein C in vivo benefits in sepsis and stroke.PAR1 偏向性信号对于活化蛋白 C 在败血症和中风中的体内获益是必需的。
Blood. 2018 Mar 15;131(11):1163-1171. doi: 10.1182/blood-2017-10-810895. Epub 2018 Jan 17.
3
The Immunoregulatory Activities of Activated Protein C in Inflammatory Disease.活化蛋白 C 在炎症性疾病中的免疫调节活性。
Semin Thromb Hemost. 2018 Mar;44(2):167-175. doi: 10.1055/s-0037-1608910. Epub 2017 Dec 12.
4
A novel protein C-factor VII chimera provides new insights into the structural requirements for cytoprotective protease-activated receptor 1 signaling.一种新型蛋白 C 因子 VII 嵌合体为保护性蛋白酶激活受体 1 信号转导的结构要求提供了新的见解。
J Thromb Haemost. 2017 Nov;15(11):2198-2207. doi: 10.1111/jth.13807. Epub 2017 Sep 21.
5
Apolipoprotein E Receptor 2 Mediates Activated Protein C-Induced Endothelial Akt Activation and Endothelial Barrier Stabilization.载脂蛋白E受体2介导活化蛋白C诱导的内皮细胞Akt激活和内皮屏障稳定。
Arterioscler Thromb Vasc Biol. 2016 Mar;36(3):518-24. doi: 10.1161/ATVBAHA.115.306795. Epub 2016 Jan 21.
6
Activated protein C β-glycoform promotes enhanced noncanonical PAR1 proteolysis and superior resistance to ischemic injury.活化蛋白 C β-糖型促进增强的非经典 PAR1 蛋白水解作用和对缺血性损伤的更好抗性。
Blood. 2015 Aug 13;126(7):915-9. doi: 10.1182/blood-2015-03-632877. Epub 2015 Jun 17.
7
Activated protein C: biased for translation.活化蛋白C：偏向翻译。
Blood. 2015 May 7;125(19):2898-907. doi: 10.1182/blood-2015-02-355974. Epub 2015 Mar 30.
8
Re-evaluation of the anticoagulant properties of high-density lipoprotein-brief report.高密度脂蛋白抗凝特性的重新评估——简要报告
Arterioscler Thromb Vasc Biol. 2015 Mar;35(3):570-2. doi: 10.1161/ATVBAHA.114.304938. Epub 2014 Dec 30.
9
Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc.活化蛋白 C 通过表观遗传抑制氧化还原酶 p66Shc 改善糖尿病肾病。
Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):648-53. doi: 10.1073/pnas.1218667110. Epub 2012 Dec 24.
10
Biased agonism of protease-activated receptor 1 by activated protein C caused by noncanonical cleavage at Arg46.激活蛋白 C 通过非典型切割精氨酸 46 导致蛋白酶激活受体 1 的偏性激动。
Blood. 2012 Dec 20;120(26):5237-46. doi: 10.1182/blood-2012-08-452169. Epub 2012 Nov 13.

载脂蛋白 A-I 增强活化蛋白 C 的细胞保护活性。

Apolipoprotein A-I enhances activated protein C cytoprotective activity.

机构信息

National Children's Research Centre, Our Lady's Children's Hospital Crumlin, Crumlin, Dublin, Ireland.

Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland.

出版信息

Blood Adv. 2020 Jun 9;4(11):2404-2408. doi: 10.1182/bloodadvances.2019001316.

DOI:10.1182/bloodadvances.2019001316
PMID:32484855
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7284090/
Abstract

High-density lipoprotein and apolipoprotein A-I enhance activated protein C cytoprotective activity. High-density lipoprotein and apolipoprotein A-I significantly increase the rate at which activated protein C degrades cytotoxic extracellular histones.

摘要

高密度脂蛋白和载脂蛋白 A-I 增强活化蛋白 C 的细胞保护活性。高密度脂蛋白和载脂蛋白 A-I 显著增加了活化蛋白 C 降解细胞毒性细胞外组蛋白的速率。