Department of Anesthesiology, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510080, China; Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510080, China.
The Marine Biomedical Research Institute, Guangdong Medical University, Zhanjiang 524023, China.
Life Sci. 2020 Sep 1;256:117885. doi: 10.1016/j.lfs.2020.117885. Epub 2020 May 30.
Inflammatory and neuropathic pain is initiated by tissue inflammation and nerve injury, respectively. Both are characterized by increased activity in the peripheral and central nervous system, where multiple inflammatory cytokines and other active molecules activate different signaling pathways that involve in the development and/or maintenance of pain. P38 mitogen-activated protein kinase (MAPK) is one member of the MAPK family, which is activated in neurons and glia and contributes importantly to inflammatory and neuropathic pain. The aim of this review is to summarize the latest advances made about the implication of p38 MAPK signaling cascade in pain. It can deepen our understanding of the molecular mechanisms of pain and may help to offer new targets for pain treatment.
炎症性疼痛和神经性疼痛分别由组织炎症和神经损伤引发。两者的特征均为外周和中枢神经系统活动增加，其中多种炎症细胞因子和其他活性分子激活不同的信号通路，参与疼痛的发生和/或维持。p38 丝裂原活化蛋白激酶（MAPK）是 MAPK 家族的一员，在神经元和神经胶质细胞中被激活，并对炎症性疼痛和神经性疼痛有重要贡献。本综述旨在总结 p38 MAPK 信号级联在疼痛中的作用的最新进展。这可以加深我们对疼痛分子机制的理解，并可能有助于为疼痛治疗提供新的靶点。
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