Altinsehir Mahallesi 326. Sokak No:7 Daire:20, NILÜFER, Bursa, Turkey.
Altinsehir Mahallesi 326. Sokak No:7 Daire:20, NILÜFER, Bursa, Turkey.
Neurosci Lett. 2020 Aug 24;734:135097. doi: 10.1016/j.neulet.2020.135097. Epub 2020 May 30.
The aim of this study is to determine the usefulness of Orexin-A levels in differentiating between epileptic seizures and psychogenic non-epileptic seizures in patients presenting to the emergency service with epileptic seizure-type symptoms.
A total of 80 individuals were included in this study, including 59 who presented to the emergency service within the first four hours of having been diagnosed with generalized tonic-clonic seizures (39 with epileptic seizures (ES) and 20 with pseudoseizures (PNES) and 21 controls. Orexin-A levels were measured in venous blood samples.
The mean Orexin-A levels were 5.16 ng/mL in the control group, 7.17 ng/mL in the PNES group, and 11.08 ng/mL in the ES group (Table 1). The mean Orexin-A level of the ES group was significantly different from both the control group and the PNES group (Table 1, p < 0.001); the difference between the control group and the PNES group was not significant (p > 0.05).
Results of this study suggest that blood Orexin-A may be an effective biomarker in the differential diagnosis of epileptic seizures/psychogenic non-epileptic seizures in patients presenting to the emergency service with an epileptic seizure-type clinical picture.
本研究旨在确定 Orexin-A 水平在区分急诊就诊以癫痫样发作症状就诊的癫痫发作和心因性非癫痫性发作患者中的作用。
本研究共纳入 80 名个体，包括在诊断为全面强直阵挛发作后 4 小时内就诊于急诊的 59 名患者（39 例癫痫发作（ES）和 20 例假性发作（PNES）和 21 名对照者。在静脉血样中测量 Orexin-A 水平。
对照组 Orexin-A 水平的平均值为 5.16ng/mL，PNES 组为 7.17ng/mL，ES 组为 11.08ng/mL（表 1）。ES 组的 Orexin-A 水平平均值与对照组和 PNES 组均有显著差异（表 1，p<0.001）；对照组与 PNES 组之间的差异无统计学意义（p>0.05）。
本研究结果表明，血液 Orexin-A 可能是急诊就诊以癫痫样发作临床特征就诊的癫痫发作/心因性非癫痫性发作患者鉴别诊断的有效生物标志物。
