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有糖尿病和无糖尿病患者的信念、风险认知和血脂管理:PALM 登记研究结果。

Beliefs, risk perceptions, and lipid management among patients with and without diabetes: Results from the PALM registry.

机构信息

Duke Clinical Research Institute, Durham, NC; Division of Cardiology, Department of Medicine, Duke University School of Medicine, Durham, NC.

Duke Clinical Research Institute, Durham, NC.

出版信息

Am Heart J. 2020 Jul;225:88-96. doi: 10.1016/j.ahj.2020.04.018. Epub 2020 Apr 30.

Abstract

UNLABELLED

Intensive lipid management is critical to reduce cardiovascular (CV) risk for patients with diabetes mellitus (DM).

METHODS

We performed an observational study of 7628 patients with (n = 2943) and without DM (n = 4685), enrolled in the Provider Assessment of Lipid Management (PALM) registry and treated at 140 outpatient clinics across the United States in 2015. Patient self-estimated CV risk, patient-perceived statin benefit and risk, observed statin therapy use and dosing were assessed.

RESULTS

Patients with DM were more likely to believe that their CV risk was elevated compared with patients without DM (39.1% vs 29.3%, P < .001). Patients with DM were more likely to receive a statin (74.2% vs 63.5%, P < .001) but less likely to be treated with guideline-recommended statin intensity (36.5% vs 46.9%, P < .001), driven by the low proportion (16.5%) of high risk (ASCVD risk ≥7.5%) primary prevention DM patients treated with a high intensity statin. Patients with DM treated with guideline-recommended statin intensity were more likely to believe they were at high CV risk (44.9% vs 38.4%, P = .005) and that statins can reduce this risk (41.1% vs 35.6%, P = .02), compared with patients treated with lower than guideline-recommended statin intensity. Compared with patients with an elevated HgbA1c, patients with well-controlled DM were no more likely to be on a statin (77.9% vs 79.3%, P = .43).

CONCLUSIONS

In this nationwide study, the majority of patients with DM were treated with lower than guideline-recommended statin intensity. Patient education and engagement may help providers improve lipid therapy for these high-risk patients.

摘要

目的

本研究旨在观察糖尿病(DM)患者与非 DM 患者在自我估计心血管(CV)风险、对他汀类药物治疗益处和风险的认知、他汀类药物使用和剂量等方面的差异。

方法

我们对 2015 年在美国 140 家门诊诊所接受治疗的 7628 例患者进行了一项观察性研究,其中 2943 例患者患有 DM(DM 组),4685 例患者未患有 DM(非 DM 组)。评估了患者的自我估计 CV 风险、患者对他汀类药物治疗益处和风险的认知、观察到的他汀类药物治疗使用情况和剂量。

结果

DM 患者比非 DM 患者更有可能认为自己的 CV 风险升高(39.1% vs 29.3%,P <.001)。DM 患者更有可能接受他汀类药物治疗(74.2% vs 63.5%,P <.001),但更不可能接受指南推荐的他汀类药物强度治疗(36.5% vs 46.9%,P <.001),原因是高危(ASCVD 风险≥7.5%)的初级预防 DM 患者中接受高强度他汀类药物治疗的比例较低(16.5%)。接受指南推荐的他汀类药物强度治疗的 DM 患者更有可能认为自己处于高 CV 风险(44.9% vs 38.4%,P =.005),并且认为他汀类药物可以降低这种风险(41.1% vs 35.6%,P =.02),而接受低于指南推荐的他汀类药物强度治疗的患者则不然。与糖化血红蛋白(HbA1c)升高的患者相比,血糖控制良好的 DM 患者使用他汀类药物的可能性没有更高(77.9% vs 79.3%,P =.43)。

结论

在这项全国性研究中,大多数 DM 患者接受的他汀类药物治疗强度低于指南推荐。患者教育和参与可能有助于提供者为这些高危患者改善血脂治疗。

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