Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in the Asian-Pacific Region, Changchun 130062, China.
Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Veterinary Medicine, Jilin University, OIE Collaborating Center on Foodborne Parasites in the Asian-Pacific Region, Changchun 130062, China.
Int Immunopharmacol. 2020 Aug;85:106646. doi: 10.1016/j.intimp.2020.106646. Epub 2020 May 30.
Trichinella or derived antigens have been suggested to be potential therapeutic agents for inflammatory bowel disease (IBD). We aimed to conduct a systematic review and meta-analysis of the available literature to estimate the effect of Trichinella or derived antigens on chemically induced IBD.
Studies were identified by searching the Cochrane Central Register of Controlled Trials, PubMed, Scopus, Web of Science, and Science Direct from inception to February 2020. We included articles written in English that investigated the effect of Trichinella infection and/or derived products in mouse models of IBD. Studies were pooled, and the combined standard mean difference (SMD) and 95% confidence interval (CI) were calculated using a random-effect or fixed-effect model.
Thirteen studies were eventually included in the meta-analysis. The results indicated significant differences in the disease activity index (DAI), myeloperoxidase (MPO) activity, macroscopic inflammation score, and microscopic inflammation score between the experimental group and the control group. The anti-inflammatory cytokines interleukin (IL)-4, transforming growth factor-beta (TGF-β), IL-10 and IL-13 were significantly increased in the experimental group compared with the control group, whereas the levels of the proinflammatory cytokines interferon (IFN)-γ, IL-6, TNF-α, and IL-17 were significantly decreased. The percentage of regulatory T (Treg) cells was also significantly increased, while the level of the M1 phenotypic macrophage marker iNOS was significantly decreased and the expression of the M2 phenotypic macrophage marker Arg-1 was significantly increased.
Trichinella infection or derived antigens is effective for the alleviation of IBD in mouse models.
旋毛虫或其衍生抗原被认为是治疗炎症性肠病（IBD）的潜在治疗剂。我们旨在对现有文献进行系统评价和荟萃分析，以评估旋毛虫或其衍生抗原对化学诱导的 IBD 的影响。
通过检索 Cochrane 对照试验中心注册库、PubMed、Scopus、Web of Science 和 Science Direct，从建库到 2020 年 2 月，我们确定了研究。我们纳入了研究调查旋毛虫感染和/或衍生产品对 IBD 小鼠模型影响的英文文章。使用随机效应或固定效应模型对研究进行合并，并计算合并后的标准均数差（SMD）和 95%置信区间（CI）。
最终有 13 项研究纳入荟萃分析。结果表明，实验组和对照组之间疾病活动指数（DAI）、髓过氧化物酶（MPO）活性、宏观炎症评分和微观炎症评分存在显著差异。实验组中抗炎细胞因子白细胞介素（IL）-4、转化生长因子-β（TGF-β）、IL-10 和 IL-13 显著增加，而促炎细胞因子干扰素（IFN）-γ、IL-6、TNF-α和 IL-17 水平显著降低。调节性 T（Treg）细胞的百分比也显著增加，而 M1 表型巨噬细胞标志物诱导型一氧化氮合酶（iNOS）的水平显著降低，M2 表型巨噬细胞标志物精氨酸酶-1（Arg-1）的表达显著增加。
旋毛虫感染或其衍生抗原对缓解 IBD 小鼠模型具有疗效。
