• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

皮下给予载脂蛋白 J 衍生模拟肽 d-[113-122]apoJ 可改善 LDL 和 HDL 功能并预防 LDLR-KO 小鼠的动脉粥样硬化。

Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113-122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice.

机构信息

Cardiovascular Biochemistry Group, Research Institute of the Hospital de Sant Pau (IIB Sant Pau), 08041 Barcelona, Spain.

Biochemistry and Molecular Biology Department, Universitat Autònoma de Barcelona, 08193 Cerdanyola, Spain.

出版信息

Biomolecules. 2020 May 29;10(6):829. doi: 10.3390/biom10060829.

DOI:10.3390/biom10060829
PMID:32485898
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7356811/
Abstract

Mimetic peptides are potential therapeutic agents for atherosclerosis. d-[,,,,,,,,,]apolipoprotein (apo) J (D-[,,,,,,,,,]apoJ) is a 10-residue peptide that is predicted to form a class G* amphipathic helix 6 from apoJ; it shows anti-inflammatory and anti-atherogenic properties. In the present study, we analyzed the effect of d-[,,,,,,,,,]apoJ in low-density lipoprotein receptor knockout mice(LDLR-KO) on the development of atherosclerosis and lipoprotein function. Fifteen-week-old female LDLR-KO mice fed an atherogenic Western-type diet were treated for eight weeks with d-[,,,,,,,,,]apoJ peptide, a scrambled peptide, or vehicle. Peptides were administered subcutaneously three days per week (200 µg in 100 µL of saline). After euthanasia, blood and hearts were collected and the aortic arch was analyzed for the presence of atherosclerotic lesions. Lipoproteins were isolated and their composition and functionality were studied. The extent of atherosclerotic lesions was 43% lower with d-[,,,,,,,,,]apoJ treatment than with the vehicle or scramble. The lipid profile was similar between groups, but the high-density lipoprotein (HDL) of d-[,,,,,,,,,]apoJ-treated mice had a higher antioxidant capacity and increased ability to promote cholesterol efflux than the control group. In addition, low-density lipoprotein (LDL) from d-[,,,,,,,,,]apoJ-treated mice was more resistant to induced aggregation and presented lower electronegativity than in mice treated with d-[,,,,,,,,,]apoJ. Our results demonstrate that the d-[,,,,,,,,,]apoJ peptide prevents the extent of atherosclerotic lesions, which could be partially explained by the improvement of lipoprotein functionality.

摘要

模拟肽是动脉粥样硬化的潜在治疗剂。载脂蛋白（apo）J 的 10 肽（D-[,,,,,,,,,]apoJ）预计形成 apoJ 中的 G* 两亲性螺旋 6；它显示出抗炎和抗动脉粥样硬化特性。在本研究中，我们分析了 D-[,,,,,,,,,]apoJ 在低密度脂蛋白受体敲除小鼠（LDLR-KO）中对动脉粥样硬化发展和脂蛋白功能的影响。15 周龄雌性 LDLR-KO 小鼠喂食致动脉粥样硬化的西方饮食 8 周，并用 D-[,,,,,,,,,]apoJ 肽、乱序肽或载体处理。肽每周皮下给药 3 天（100µL 盐水中 200µg）。安乐死后采集血液和心脏，并分析主动脉弓是否存在动脉粥样硬化病变。分离脂蛋白并研究其组成和功能。与载体或乱序肽相比，D-[,,,,,,,,,]apoJ 处理使动脉粥样硬化病变程度降低 43%。各组的脂质谱相似，但 D-[,,,,,,,,,]apoJ 处理组的高密度脂蛋白（HDL）具有更高的抗氧化能力和增加的胆固醇流出能力，高于对照组。此外，与 D-[,,,,,,,,,]apoJ 处理的小鼠相比，D-[,,,,,,,,,]apoJ 处理的小鼠的低密度脂蛋白（LDL）更能抵抗诱导的聚集，并且具有较低的电负性。我们的结果表明，D-[,,,,,,,,,]apoJ 肽可预防动脉粥样硬化病变的程度，这部分可以通过改善脂蛋白功能来解释。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/d4b062fe9dd6/biomolecules-10-00829-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/b274a04ce08d/biomolecules-10-00829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/6a3b035039f0/biomolecules-10-00829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/1adab2322a94/biomolecules-10-00829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/636080cff367/biomolecules-10-00829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/24fa8a03e89d/biomolecules-10-00829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/42b698884fac/biomolecules-10-00829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/a81a46f48e21/biomolecules-10-00829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/b90c9d079e1d/biomolecules-10-00829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/61b4786aa835/biomolecules-10-00829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/d4b062fe9dd6/biomolecules-10-00829-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/b274a04ce08d/biomolecules-10-00829-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/6a3b035039f0/biomolecules-10-00829-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/1adab2322a94/biomolecules-10-00829-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/636080cff367/biomolecules-10-00829-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/24fa8a03e89d/biomolecules-10-00829-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/42b698884fac/biomolecules-10-00829-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/a81a46f48e21/biomolecules-10-00829-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/b90c9d079e1d/biomolecules-10-00829-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/61b4786aa835/biomolecules-10-00829-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/990c/7356811/d4b062fe9dd6/biomolecules-10-00829-g010.jpg

相似文献

1
Subcutaneous Administration of Apolipoprotein J-Derived Mimetic Peptide d-[113-122]apoJ Improves LDL and HDL Function and Prevents Atherosclerosis in LDLR-KO Mice.皮下给予载脂蛋白 J 衍生模拟肽 d-[113-122]apoJ 可改善 LDL 和 HDL 功能并预防 LDLR-KO 小鼠的动脉粥样硬化。
Biomolecules. 2020 May 29;10(6):829. doi: 10.3390/biom10060829.
2
Low-density lipoprotein aggregation is inhibited by apolipoprotein J-derived mimetic peptide D-[113-122]apoJ.载脂蛋白 J 衍生模拟肽 D-[113-122]apoJ 抑制低密度脂蛋白聚集。
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158541. doi: 10.1016/j.bbalip.2019.158541. Epub 2019 Oct 28.
3
Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.轻度氧化的低密度脂蛋白会导致载脂蛋白J/对氧磷酶比率升高。
J Clin Invest. 1997 Apr 15;99(8):2005-19. doi: 10.1172/JCI119369.
4
An oral apoJ peptide renders HDL antiinflammatory in mice and monkeys and dramatically reduces atherosclerosis in apolipoprotein E-null mice.口服载脂蛋白J肽可使小鼠和猴子体内的高密度脂蛋白具有抗炎作用，并显著减轻载脂蛋白E基因敲除小鼠的动脉粥样硬化。
Arterioscler Thromb Vasc Biol. 2005 Sep;25(9):1932-7. doi: 10.1161/01.ATV.0000174589.70190.e2. Epub 2005 Jun 16.
5
Ambient ultrafine particles alter lipid metabolism and HDL anti-oxidant capacity in LDLR-null mice.环境超细颗粒物改变 LDLR 基因敲除小鼠的脂代谢和高密度脂蛋白的抗氧化能力。
J Lipid Res. 2013 Jun;54(6):1608-1615. doi: 10.1194/jlr.M035014. Epub 2013 Apr 6.
6
Procollagen C-endopeptidase Enhancer Protein 2 (PCPE2) Reduces Atherosclerosis in Mice by Enhancing Scavenger Receptor Class B1 (SR-BI)-mediated High-density Lipoprotein (HDL)-Cholesteryl Ester Uptake.前胶原C端肽酶增强蛋白2（PCPE2）通过增强清道夫受体B1类（SR-BI）介导的高密度脂蛋白（HDL）胆固醇酯摄取来减轻小鼠动脉粥样硬化。
J Biol Chem. 2015 Jun 19;290(25):15496-15511. doi: 10.1074/jbc.M115.646240. Epub 2015 May 6.
7
Cholesterol reduction and atherosclerosis inhibition by bezafibrate in low-density lipoprotein receptor knockout mice.苯扎贝特对低密度脂蛋白受体敲除小鼠的胆固醇降低及动脉粥样硬化抑制作用
Hypertens Res. 2008 May;31(5):999-1005. doi: 10.1291/hypres.31.999.
8
Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies.晚期鼠动脉粥样硬化病变的消退和稳定：LDL 降低和 HDL 升高基因转移策略的比较。
J Mol Med (Berl). 2011 Jun;89(6):555-67. doi: 10.1007/s00109-011-0722-x. Epub 2011 Jan 21.
9
Increased low-density lipoprotein oxidation and impaired high-density lipoprotein antioxidant defense are associated with increased macrophage homing and atherosclerosis in dyslipidemic obese mice: LCAT gene transfer decreases atherosclerosis.在血脂异常的肥胖小鼠中，低密度脂蛋白氧化增加和高密度脂蛋白抗氧化防御受损与巨噬细胞归巢增加及动脉粥样硬化相关：卵磷脂胆固醇酰基转移酶基因转移可减轻动脉粥样硬化。
Circulation. 2003 Apr 1;107(12):1640-6. doi: 10.1161/01.CIR.0000056523.08033.9F. Epub 2003 Mar 24.
10
A new synthetic class A amphipathic peptide analogue protects mice from diet-induced atherosclerosis.一种新型合成的A类两亲性肽类似物可保护小鼠免受饮食诱导的动脉粥样硬化。
J Lipid Res. 2001 Apr;42(4):545-52.

引用本文的文献

1
Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets.富含脂质的泡沫细胞在动脉粥样硬化病理学中的作用：为新的治疗靶点提供启示。
Expert Opin Ther Targets. 2023 Jul-Dec;27(12):1231-1245. doi: 10.1080/14728222.2023.2288272. Epub 2023 Dec 30.
2
Apolipoproteins as potential communicators play an essential role in the pathogenesis and treatment of early atherosclerosis.载脂蛋白作为潜在的通讯者，在早期动脉粥样硬化的发病机制和治疗中发挥着重要作用。
Int J Biol Sci. 2023 Aug 21;19(14):4493-4510. doi: 10.7150/ijbs.86475. eCollection 2023.
3
Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy.

本文引用的文献

1
The mystery of evacetrapib - why are CETP inhibitors failing?依折麦布的谜团——为什么胆固醇酯转运蛋白抑制剂会失败？
Expert Rev Cardiovasc Ther. 2020 Mar;18(3):127-130. doi: 10.1080/14779072.2020.1745633. Epub 2020 Mar 21.
2
A dual apolipoprotein C-II mimetic-apolipoprotein C-III antagonist peptide lowers plasma triglycerides.一种双重载脂蛋白 C-II 模拟肽-载脂蛋白 C-III 拮抗剂可降低血浆甘油三酯。
Sci Transl Med. 2020 Jan 29;12(528). doi: 10.1126/scitranslmed.aaw7905.
3
Low-density lipoprotein aggregation is inhibited by apolipoprotein J-derived mimetic peptide D-[113-122]apoJ.
候选基因变异与载脂蛋白E/载脂蛋白J循环水平与脑淀粉样血管病常见神经影像学特征的关联
Front Aging Neurosci. 2023 Apr 11;15:1134399. doi: 10.3389/fnagi.2023.1134399. eCollection 2023.
4
Recombinant Human Clusterin Seals Damage to the Ocular Surface Barrier in a Mouse Model of Ophthalmic Preservative-Induced Epitheliopathy.重组人聚集素可封闭眼科防腐剂诱导的眼表上皮病模型中眼表屏障的损伤。
Int J Mol Sci. 2023 Jan 4;24(2):981. doi: 10.3390/ijms24020981.
5
Alterations of HDL's to piHDL's Proteome in Patients with Chronic Inflammatory Diseases, and HDL-Targeted Therapies.慢性炎症性疾病患者中高密度脂蛋白（HDL）向前β高密度脂蛋白（piHDL）蛋白质组的改变以及针对HDL的疗法
Pharmaceuticals (Basel). 2022 Oct 18;15(10):1278. doi: 10.3390/ph15101278.
6
Effect of Apolipoprotein E ε4 Allele on the Progression of Carotid Atherosclerosis Through Apolipoprotein Levels.载脂蛋白Eε4等位基因通过载脂蛋白水平对颈动脉粥样硬化进展的影响
Pharmgenomics Pers Med. 2022 Jun 21;15:653-661. doi: 10.2147/PGPM.S367471. eCollection 2022.
7
Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells.抗低密度脂蛋白（LDL）聚集的肽可抑制胰腺肿瘤细胞内胆固醇酯的负载及增殖。
Cancers (Basel). 2022 Feb 11;14(4):890. doi: 10.3390/cancers14040890.
8
Apolipoprotein and LRP1-Based Peptides as New Therapeutic Tools in Atherosclerosis.载脂蛋白和基于低密度脂蛋白受体相关蛋白1的肽作为动脉粥样硬化新的治疗工具
J Clin Med. 2021 Aug 13;10(16):3571. doi: 10.3390/jcm10163571.
9
Changes in the Composition and Function of Lipoproteins after Bariatric Surgery in Patients with Severe Obesity.重度肥胖患者接受减肥手术后脂蛋白的组成和功能变化
J Clin Med. 2021 Apr 16;10(8):1716. doi: 10.3390/jcm10081716.
10
Aggregation Susceptibility of Low-Density Lipoproteins-A Novel Modifiable Biomarker of Cardiovascular Risk.低密度脂蛋白的聚集易感性——一种新型的可改变的心血管风险生物标志物。
J Clin Med. 2021 Apr 19;10(8):1769. doi: 10.3390/jcm10081769.
载脂蛋白 J 衍生模拟肽 D-[113-122]apoJ 抑制低密度脂蛋白聚集。
Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Feb;1865(2):158541. doi: 10.1016/j.bbalip.2019.158541. Epub 2019 Oct 28.
4
2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk.2019年欧洲心脏病学会/欧洲动脉粥样硬化学会血脂异常管理指南：通过血脂修饰降低心血管风险
Eur Heart J. 2020 Jan 1;41(1):111-188. doi: 10.1093/eurheartj/ehz455.
5
Mouse Models for Atherosclerosis Research-Which Is My Line?动脉粥样硬化研究的小鼠模型——我的选择是哪一种？
Front Cardiovasc Med. 2019 Apr 12;6:46. doi: 10.3389/fcvm.2019.00046. eCollection 2019.
6
Inflammation and its resolution in atherosclerosis: mediators and therapeutic opportunities.动脉粥样硬化中的炎症及其解决：介质和治疗机会。
Nat Rev Cardiol. 2019 Jul;16(7):389-406. doi: 10.1038/s41569-019-0169-2.
7
Nonalcoholic Fatty Liver Disease and the Heart: JACC State-of-the-Art Review.非酒精性脂肪性肝病与心脏：美国心脏病学会的现状评价。
J Am Coll Cardiol. 2019 Mar 5;73(8):948-963. doi: 10.1016/j.jacc.2018.11.050.
8
Medical Therapy for Long-Term Prevention of Atherothrombosis Following an Acute Coronary Syndrome: JACC State-of-the-Art Review.急性冠状动脉综合征后长期预防动脉粥样血栓形成的医学治疗：美国心脏病学会最新观点综述。
J Am Coll Cardiol. 2018 Dec 11;72(23 Pt A):2886-2903. doi: 10.1016/j.jacc.2018.09.052.
9
Apoprotein E and Reverse Cholesterol Transport.载脂蛋白 E 与胆固醇逆转运。
Int J Mol Sci. 2018 Nov 6;19(11):3479. doi: 10.3390/ijms19113479.
10
Plasma high density lipoproteins: Therapeutic targeting and links to atherogenic inflammation.血浆高密度脂蛋白：治疗靶点与动脉粥样硬化炎症的关联。
Atherosclerosis. 2018 Sep;276:39-43. doi: 10.1016/j.atherosclerosis.2018.07.004. Epub 2018 Jul 4.