Division of Gastroenterology and Hepatology, Department of Medicine, University of Missouri, Columbia, MO 65212, USA.
Department of Pharmaceutical Sciences, Rangel College of Pharmacy, Texas A&M University, Kingsville, TX 78363, USA.
Int J Mol Sci. 2020 May 31;21(11):3956. doi: 10.3390/ijms21113956.
Many synthetic drugs and monoclonal antibodies are currently in use to treat Inflammatory Bowel Disease (IBD). However, they all are implicated in causing severe side effects and long-term use results in many complications. Numerous in vitro and in vivo experiments demonstrate that phytochemicals and natural macromolecules from plants and animals reduce IBD-related complications with encouraging results. Additionally, many of them modify enzymatic activity, alleviate oxidative stress, and downregulate pro-inflammatory transcriptional factors and cytokine secretion. Translational significance of natural nanomedicine and strategies to investigate future natural product-based nanomedicine is discussed. Our focus in this review is to summarize the use of phytochemicals and macromolecules encapsulated in nanoparticles for the treatment of IBD and IBD-associated colorectal cancer.
目前有许多合成药物和单克隆抗体被用于治疗炎症性肠病（IBD）。然而，它们都可能导致严重的副作用，长期使用会导致许多并发症。大量的体外和体内实验表明，植物和动物中的植物化学物质和天然大分子可以减少与 IBD 相关的并发症，结果令人鼓舞。此外，它们中的许多物质还可以调节酶活性、减轻氧化应激、下调促炎转录因子和细胞因子的分泌。本文讨论了天然纳米药物的转化意义和未来基于天然产物的纳米药物的研究策略。我们在本文中的重点是总结纳米颗粒包封的植物化学物质和大分子在治疗 IBD 和 IBD 相关结直肠癌中的应用。
