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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Manchester K M, Amy N K

Department of Nutritional Sciences, University of California, Berkeley 94720.

Int J Biochem. 1988;20(10):1061-6. doi: 10.1016/0020-711x(88)90250-9.

Xanthine oxidase (XO) was purified from livers of C57B1/6 mice. Antibodies generated against the purified protein were used in an immunoassay to measure total XO protein. 2. Both the specific activity and amount of XO protein were greater in the proximal small intestine than in the liver. A pool of inactive enzyme was present in the small intestine which developed after weaning. 3. Male C57B1/6 mice had the same XO specific activity as females and neither the hepatic nor the intestinal XO activity were affected by the level of dietary protein. 4. When mice were fed diets with tungsten, XO activity was lost and the amount of XO protein in the small intestine was decreased.

黄嘌呤氧化酶（XO）从C57B1/6小鼠的肝脏中纯化得到。针对纯化蛋白产生的抗体用于免疫测定，以测量总XO蛋白。2. 近端小肠中XO蛋白的比活性和含量均高于肝脏。小肠中存在一组断奶后产生的无活性酶。3. 雄性C57B1/6小鼠的XO比活性与雌性相同，膳食蛋白质水平对肝脏和肠道的XO活性均无影响。4. 当给小鼠喂食含钨饮食时，XO活性丧失，小肠中XO蛋白的含量降低。

Manchester K M, Amy N K

Department of Nutritional Sciences, University of California, Berkeley 94720.

Int J Biochem. 1988;20(10):1061-6. doi: 10.1016/0020-711x(88)90250-9.

Xanthine oxidase (XO) was purified from livers of C57B1/6 mice. Antibodies generated against the purified protein were used in an immunoassay to measure total XO protein. 2. Both the specific activity and amount of XO protein were greater in the proximal small intestine than in the liver. A pool of inactive enzyme was present in the small intestine which developed after weaning. 3. Male C57B1/6 mice had the same XO specific activity as females and neither the hepatic nor the intestinal XO activity were affected by the level of dietary protein. 4. When mice were fed diets with tungsten, XO activity was lost and the amount of XO protein in the small intestine was decreased.

黄嘌呤氧化酶（XO）从C57B1/6小鼠的肝脏中纯化得到。针对纯化蛋白产生的抗体用于免疫测定，以测量总XO蛋白。2. 近端小肠中XO蛋白的比活性和含量均高于肝脏。小肠中存在一组断奶后产生的无活性酶。3. 雄性C57B1/6小鼠的XO比活性与雌性相同，膳食蛋白质水平对肝脏和肠道的XO活性均无影响。4. 当给小鼠喂食含钨饮食时，XO活性丧失，小肠中XO蛋白的含量降低。