实验性糖尿病对大鼠体内肝脏苯丙氨酸羟化酶的影响。

Effects of experimental diabetes on rat hepatic phenylalanine hydroxylase in vivo.

Howard K, Donlon J

Department of Biochemistry, University College Galway, Ireland.

Int J Biochem. 1988;20(11):1231-4. doi: 10.1016/0020-711x(88)90224-8.

Abstract

The stimulated levels of phenylanine hydroxylase activity in liver extracts from streptozotocin-induced diabetic rats (Donlon and Beirne, 1982) have been correlated with an increased rate of phenylalanine catabolism in vivo. 2. The levels of hepatic phenylalanine hydroxylase protein in diabetic rats become elevated. This effect is not seen in diabetic animals concurrently treated with insulin. 3. The rate of synthesis of liver phenylalanine hydroxylase in 5-day diabetics is 260% that of control animals. 4. These observations are discussed with reference to the regulation of hepatic phenylalanine hydroxylase and phenylanine metabolism in rats.

摘要

链脲佐菌素诱导的糖尿病大鼠肝脏提取物中苯丙氨酸羟化酶活性的刺激水平（Donlon和Beirne，1982年）与体内苯丙氨酸分解代谢速率的增加相关。2. 糖尿病大鼠肝脏中苯丙氨酸羟化酶蛋白水平升高。在用胰岛素同时治疗的糖尿病动物中未观察到这种效应。3. 5天龄糖尿病大鼠肝脏苯丙氨酸羟化酶的合成速率是对照动物的260%。4. 参照大鼠肝脏苯丙氨酸羟化酶的调节和苯丙氨酸代谢对这些观察结果进行了讨论。