Wacker Chemie AG, Burghausen, Germany.
Wacker Chemical Corporation, Ann Arbor, USA.
Mater Sci Eng C Mater Biol Appl. 2020 Aug;113:111001. doi: 10.1016/j.msec.2020.111001. Epub 2020 Apr 23.
Due to their high biocompatibility silicone elastomers are the material of choice in many sensitive health care applications. However, the inherent hydrophobicity of the polymer makes silicones more susceptible to spontaneous protein adsorption and subsequent biofilm formation than more hydrophilic abiotic materials. Hence, the development of antimicrobial silicone elastomers could help to reduce potential biofilm-associated infections when using silicone based medical devices. In this study, we describe carboxylic-acid-modified silicone elastomers that are biocompatible and exhibit a specific antimicrobial activity against clinically relevant pathogens even after being stored in common packaging materials.
由于其高度的生物相容性，硅橡胶是许多敏感的医疗保健应用的首选材料。然而，聚合物固有的疏水性使得硅橡胶比更亲水的非生物材料更容易自发地吸附蛋白质并随后形成生物膜。因此，开发抗菌硅橡胶可以帮助减少使用基于硅的医疗器械时潜在的生物膜相关感染。在本研究中，我们描述了羧酸改性的硅橡胶，它具有生物相容性，并具有针对临床相关病原体的特定抗菌活性，即使在储存在常见包装材料中也是如此。
