Cancer Discov. 2020 Jul;10(7):896. doi: 10.1158/2159-8290.CD-NB2020-053. Epub 2020 Jun 2.
Adjuvant treatment with the tyrosine kinase inhibitor osimertinib will likely become a new standard of care in patients with -mutant non-small cell lung cancer. In the phase III ADAURA trial, 90% of patients with stage II-IIIA disease who received osimertinib were alive and free of cancer at 2 years, compared with 44% who received a placebo-results considered so striking that researchers unblinded the trial early.
奥希替尼的辅助治疗可能成为 - 突变型非小细胞肺癌患者的新治疗标准。在 III 期 ADAURA 试验中,接受奥希替尼治疗的 II 期-IIIA 期疾病患者中有 90%在 2 年内仍然存活且无癌症,而接受安慰剂治疗的患者则为 44%-这一结果令人瞩目,以至于研究人员提前揭盲了试验。