超声激活手术设备在胃癌手术中的肿瘤安全性。
Oncological Safety of Ultrasonically Activated Surgical Devices During Gastric Cancer Surgery.
机构信息
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan
Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto, Japan.
出版信息
Anticancer Res. 2020 Jun;40(6):3163-3167. doi: 10.21873/anticanres.14298.
BACKGROUND/AIM: Ultrasonically activated surgical devices (USADs) have become indispensable instruments for gastrointestinal surgery. In this study, we investigated the oncological safety of the use of USADs.
MATERIALS AND METHODS
We harvested and cultivated the splashes and mist scattered from an USAD when cutting MKN45-derived cancer nodules. Seven days later, we observed viable cancer cells and the total number of cells was counted. The histopathology of the nodules cut by the USAD was also examined.
RESULTS
The existence of viable cancer cells was confirmed by ex vivo cell culture. The number of viable cancer cells was reduced by slow grasping of the USAD. The surface of cancerous tissue cut by the USAD was partially heat-denatured, however, there were some parts in which cancerous tissue was exposed on the surface.
CONCLUSION
Surgeons should recognize the possibility that cancer cells may be scattered by USAD use.
背景/目的：超声激活手术设备（USADs）已成为胃肠外科学中不可或缺的工具。本研究旨在探讨 USAD 使用的肿瘤安全性。
材料和方法
我们采集和培养了 USAD 在切割 MKN45 衍生的癌结节时飞溅和雾化的飞沫。7 天后，观察有活力的癌细胞，并计算总细胞数。还检查了 USAD 切割的结节的组织病理学。
结果
通过体外细胞培养证实了有活力的癌细胞的存在。通过缓慢抓住 USAD 可减少有活力的癌细胞数量。USAD 切割的癌组织表面部分热变性，但表面上仍有部分癌组织暴露。
结论
外科医生应该认识到 USAD 使用可能会导致癌细胞散落的可能性。
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