Department of Urology, Medical School, University of Pecs, Pecs, Hungary.
Institute of Biochemistry, University of Muenster, Muenster, Germany.
Anticancer Res. 2020 Jun;40(6):3485-3489. doi: 10.21873/anticanres.14335.
BACKGROUND/AIM: Despite early detection by widespread use of abdominal imaging more than 40% of patients with conventional renal cell carcinoma (RCC) will die due to metastatic disease. Small kinase inhibitors for AXL receptor tyrosine kinase may delay the progression of metastatic cRCC.
We analysed AXL expression by immunohistochemistry on tissue multi arrays of 691 conventional RCC without metastasis at the time of nephrectomy.
The Kaplan-Meier survival analysis indicated a poor disease-specific survival rates for patients with tumour showing cytoplasmic AXL staining, whereas expression on the cell membrane is associated with excellent disease outcome. Multivariate Cox regression analysis identified cytoplasmic AXL expression as an independent prognostic factor indicating a five-times higher risk of postoperative tumour progression (RR=5.048; 95% CI=2.391-10.657; p<0.001).
Detecting cytoplasmic expression of AXL can be used to define a subset of conventional RCC with high risk of progression, thus identifying patients for more aggressive surveillance and adjuvant AXL inhibitor treatment as early as possible.
背景/目的：尽管广泛使用腹部成像进行早期检测，但超过 40%的传统肾细胞癌（RCC）患者仍会因转移性疾病而死亡。AXL 受体酪氨酸激酶的小分子激酶抑制剂可能会延迟转移性 cRCC 的进展。
我们通过免疫组织化学分析了 691 例在肾切除时没有转移的常规 RCC 组织的 AXL 表达情况。
Kaplan-Meier 生存分析表明，肿瘤细胞质 AXL 染色的患者疾病特异性生存率较差，而细胞膜表达与良好的疾病结果相关。多变量 Cox 回归分析确定细胞质 AXL 表达为独立的预后因素，表明术后肿瘤进展的风险增加五倍（RR=5.048；95%CI=2.391-10.657；p<0.001）。
检测 AXL 的细胞质表达可用于定义具有高进展风险的常规 RCC 亚组，从而尽早识别出需要更积极监测和辅助 AXL 抑制剂治疗的患者。
