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Response to the letter to the editor by Hafer and Johnson concerning 'Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain'.

作者信息

Ottoboni Thomas, Quart Barry, Pawasauskas Jayne, Dasta Joseph F, Pollak Richard A, Viscusi Eugene R

机构信息

Heron Therapeutics, Inc, San Diego, California, USA

Heron Therapeutics, Inc, San Diego, California, USA.

出版信息

Reg Anesth Pain Med. 2020 Dec;45(12):1031-1032. doi: 10.1136/rapm-2020-101488. Epub 2020 Jun 2.

DOI:10.1136/rapm-2020-101488
PMID:32487703
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7691810/
Abstract
摘要

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1
Response to the letter to the editor by Hafer and Johnson concerning 'Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain'.对Hafer和Johnson致编辑的信的回复，信的内容涉及“HTX-011的作用机制：一种用于术后疼痛的新型长效双作用局部麻醉制剂” 。
Reg Anesth Pain Med. 2020 Dec;45(12):1031-1032. doi: 10.1136/rapm-2020-101488. Epub 2020 Jun 2.
2
Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain.HTX-011的作用机制：一种用于术后疼痛的新型缓释双效局部麻醉制剂。
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Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain.HTX-011的作用机制：一种用于术后疼痛的新型长效双作用局部麻醉制剂。
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引用本文的文献

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HTX-011 in Combination with Multimodal Analgesic Regimen Minimized Severe Pain and Opioid Use after Total Knee Arthroplasty in an Open-Label Study.一项开放性研究表明，HTX-011 联合多模式镇痛方案可减轻全膝关节置换术后的重度疼痛和阿片类药物使用。
J Knee Surg. 2023 Jul;36(9):925-932. doi: 10.1055/s-0042-1747945. Epub 2022 Jun 10.
2
Nanotherapeutic-directed approaches to analgesia.靶向治疗的镇痛方法。
Trends Pharmacol Sci. 2021 Jul;42(7):527-550. doi: 10.1016/j.tips.2021.03.007. Epub 2021 Apr 19.
3
Efficacy of New Long-Acting Bupivacaine HTX-011 in Providing Pain Relief for Patients Undergoing Elective Surgery - A Meta-analysis of Prospective Randomized Controlled Trials.新型长效布比卡因HTX-011为择期手术患者提供疼痛缓解的疗效——前瞻性随机对照试验的荟萃分析
Anesth Essays Res. 2020 Apr-Jun;14(2):288-294. doi: 10.4103/aer.AER_34_20. Epub 2020 Oct 12.

本文引用的文献

1
Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain.HTX-011的作用机制：一种用于术后疼痛的新型缓释双效局部麻醉制剂。
Reg Anesth Pain Med. 2020 Dec;45(12):1030-1031. doi: 10.1136/rapm-2020-101430. Epub 2020 Jun 2.
2
Mechanism of action of HTX-011: a novel, extended-release, dual-acting local anesthetic formulation for postoperative pain.HTX-011的作用机制：一种用于术后疼痛的新型长效双作用局部麻醉制剂。
Reg Anesth Pain Med. 2019 Dec 16. doi: 10.1136/rapm-2019-100714.
3
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in herniorrhaphy: results from the phase 3 EPOCH 2 study.HTX-011 在疝修补术中相较于布比卡因盐酸盐降低了疼痛强度和阿片类药物的使用：来自 3 期 EPOCH 2 研究的结果。
Hernia. 2019 Dec;23(6):1071-1080. doi: 10.1007/s10029-019-02023-6. Epub 2019 Aug 19.
4
HTX-011 reduced pain intensity and opioid consumption versus bupivacaine HCl in bunionectomy: phase III results from the randomized EPOCH 1 study.在拇外翻手术中，与盐酸布比卡因相比，HTX-011降低了疼痛强度和阿片类药物的消耗量：随机EPOCH 1研究的III期结果。
Reg Anesth Pain Med. 2019 May 21. doi: 10.1136/rapm-2019-100531.
5
Local anesthetic failure associated with inflammation: verification of the acidosis mechanism and the hypothetic participation of inflammatory peroxynitrite.局部麻醉失败与炎症相关：酸中毒机制的验证及炎症过氧亚硝酸盐的假设性参与。
J Inflamm Res. 2008;1:41-8. doi: 10.2147/jir.s3982. Epub 2008 Nov 13.