Division of Infectious Diseases, Duke University Medical Center, Durham, North Carolina, USA.
Curr Opin Organ Transplant. 2020 Aug;25(4):377-382. doi: 10.1097/MOT.0000000000000780.
Vascularized composite allograft (VCA) transplants constitute multiple tissues transplanted together as one functional unit. These procedures are increasing in frequency and complexity, yet data about graft survival, quality of life, and infection risk remain limited.
Informative guidance for this patient population is often inferred from the solid organ transplantation literature. Yet, it is important to understand that VCA transplantation additionally carries its own significant and distinctive risk factors for infection.
In this review, we give an overview of previously described infectious complications of VCA transplantation in the literature, discuss risk factors for future infection in these patients, and discuss how to manage such obstacles.
血管化复合组织同种异体移植（VCA）将多种组织作为一个功能单元一起移植。这些手术的频率和复杂性都在增加，但有关移植物存活率、生活质量和感染风险的数据仍然有限。
对于这类患者人群，通常从实体器官移植文献中推断出有用的指导。然而，重要的是要理解，VCA 移植还存在其自身的重大和独特的感染风险因素。
在这篇综述中，我们概述了文献中描述的 VCA 移植的先前感染并发症，讨论了这些患者未来感染的风险因素，并讨论了如何应对这些障碍。
