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紧密相连:精神分析如何减轻代际DNA创伤。

Bound Together: How Psychoanalysis Diminishes Inter-generational DNA Trauma.

作者信息

Colangeli Roberto

机构信息

Manhattan Institute for Psychoanalysis, 245 E 13 Street, New York, NY, 10003, USA.

出版信息

Am J Psychoanal. 2020 Jun;80(2):196-218. doi: 10.1057/s11231-020-09247-x.

DOI:10.1057/s11231-020-09247-x
PMID:32488025
Abstract

The concept of intergenerational transmission of trauma plays a fundamental role in psychoanalysis. While it is known that intergenerational trauma can be transmitted through attachment relationships, a new branch of genetics (epigenetics) has emerged to study the interaction between human behavior and changes in DNA expression. Therefore, psychoanalysis, which has proven to reduce the intergenerational transmission of trauma from a behavioral perspective, can play a positive role in regulating DNA changes caused by environmental stress. The present paper focuses on recent research suggesting a direct correlation between psychological trauma and DNA modifications. In particular, DNA changes caused by psychological trauma can be transmitted from generation to generation, validating the psychoanalytic concept of intergenerational transmission of trauma. This evidence not only supports the essential role psychoanalysis has in influencing human behavior, but also suggests that it affects not only the individuals who undergo it but their offspring, as well, via the epigenetic passage of DNA.

摘要

创伤的代际传递概念在精神分析中起着基础性作用。虽然已知代际创伤可通过依恋关系传递,但一个新的遗传学分支(表观遗传学)已出现,用于研究人类行为与DNA表达变化之间的相互作用。因此,已证明能从行为角度减少创伤代际传递的精神分析,可在调节由环境压力引起的DNA变化方面发挥积极作用。本文聚焦于近期研究,这些研究表明心理创伤与DNA修饰之间存在直接关联。特别是,由心理创伤引起的DNA变化可代代相传,这证实了创伤代际传递的精神分析概念。这一证据不仅支持了精神分析在影响人类行为方面的重要作用,还表明它不仅影响接受精神分析的个体,还会通过DNA的表观遗传传递影响他们的后代。

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本文引用的文献

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2
Genome-wide DNA methylation investigation of glucocorticoid exposure within buccal samples.口腔样本中糖皮质激素暴露的全基因组 DNA 甲基化研究。
Psychiatry Clin Neurosci. 2019 Jun;73(6):323-330. doi: 10.1111/pcn.12835. Epub 2019 Mar 28.
3
Methylation of and in Relation to Treatment Response to Mindfulness Based Stress Reduction for Posttraumatic Stress Disorder.
创伤后应激障碍中与基于正念减压治疗反应相关的[具体物质]甲基化
Front Psychiatry. 2018 Sep 18;9:418. doi: 10.3389/fpsyt.2018.00418. eCollection 2018.
4
Reduced levels of miRNAs 449 and 34 in sperm of mice and men exposed to early life stress.早期生活应激暴露的小鼠和男性精子中 miRNA 449 和 34 的水平降低。
Transl Psychiatry. 2018 May 23;8(1):101. doi: 10.1038/s41398-018-0146-2.
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Variations on the Migratory Theme: Immigrants or Exiles, Refugees or Asylees.迁徙主题的变奏:移民还是流亡者、难民还是寻求庇护者。
Psychoanal Rev. 2017 Dec;104(6):687-694. doi: 10.1521/prev.2017.104.6.687.
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The effects of DNA methylation on human psychology.DNA甲基化对人类心理的影响。
Behav Brain Res. 2018 Jul 2;346:47-65. doi: 10.1016/j.bbr.2017.12.004. Epub 2017 Dec 10.
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Parental Advisory: Maternal and Paternal Stress Can Impact Offspring Neurodevelopment.家长须知:父母的压力会影响后代的神经发育。
Biol Psychiatry. 2018 May 15;83(10):886-894. doi: 10.1016/j.biopsych.2017.10.005. Epub 2017 Oct 13.
8
Memory: Between traumatic shock and psychic historicization.记忆:介于创伤性休克与心理历史化之间。
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The Economy of the Totalitarian Mind: the Case of the Immigrant Child.极权主义思维的经济:移民儿童的案例。
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