Tegner H, Ohlsson K
Hoppe Seylers Z Physiol Chem. 1977 Apr;358(4):425-9. doi: 10.1515/bchm2.1977.358.1.425.
Normal human bronchial secretion contains protease inhibitors from plasma and an acid-stable, low molecular weight inhibitor which strongly inactivates granulocyte elastase and chymotrypsin-like cationic proteins. The distribution of this bronchial protease inhibitor in tracheal mucosa was analyzed by an indirect immunoperoxidase method. Strong peroxidase staining was obtained in the columnar ciliated epithelium of the trachea and in the sero-mucus glands. The findings support a local mucosal production of the inhibitor. Maxillary sinus mucosa was also positively stained for the inhibitor.
正常人类支气管分泌物含有来自血浆的蛋白酶抑制剂以及一种酸稳定的低分子量抑制剂，该抑制剂能强烈灭活粒细胞弹性蛋白酶和类胰凝乳蛋白酶阳离子蛋白。采用间接免疫过氧化物酶法分析了这种支气管蛋白酶抑制剂在气管黏膜中的分布。在气管的柱状纤毛上皮和浆液黏液腺中获得了强烈的过氧化物酶染色。这些发现支持该抑制剂是由局部黏膜产生的。上颌窦黏膜对该抑制剂也呈阳性染色。
