Chisari Laura Maria, Antonino Grasso, Chisari Giuseppe, Borzì Antonio Maria, Chisari Clara Grazia
Department of Biomedical and Biotechnological Sciences, University of Catania, Italy.
Department of General Surgery and Medical Surgical Specialties, University of Catania, Italy.
Ann Med Surg (Lond). 2020 May 16;55:174-176. doi: 10.1016/j.amsu.2020.04.020. eCollection 2020 Jul.
The phases of a cutaneous infection are initially the adhesion of the microorganism to the cells of the host, followed by the invasion of the tissues, than the elaboration of toxins and the escape from the defense systems of the host. The Human Amniotic Membrane (HAM) is extracted from the placenta of donors after caesarean section. The amnios is characterized by a monolayer of epithelial cells, a basement membrane and an avascular stroma of collagen. The HAM showed to promote chronic wound healing. We evaluated the "in vivo" and "in vitro" activity and efficacy of the HAM in subjects with chronic diabetic skin lesion. This clinical case showed that the HAM promote the wound healing of complex chronic skin lesion in a follow-up period of 6 months after the first graft.
皮肤感染的阶段最初是微生物与宿主细胞的黏附，随后是组织入侵，接着是毒素的产生以及从宿主防御系统中逃逸。人羊膜（HAM）是在剖宫产术后从供体胎盘提取的。羊膜的特征是有单层上皮细胞、一层基底膜和无血管的胶原基质。HAM已显示出能促进慢性伤口愈合。我们评估了HAM在患有慢性糖尿病皮肤病变的受试者中的“体内”和“体外”活性及疗效。该临床病例表明，在首次移植后的6个月随访期内，HAM促进了复杂慢性皮肤病变的伤口愈合。
