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阿斯伯格综合征

Asperger Syndrome(Archived)

作者信息

Hosseini Seyed Alireza, Molla Mohammed

机构信息

Kern Medical Center

Kern Medical

Abstract

Asperger syndrome (AS) was first described by Hans Asperger in 1944 as the behavioral characterization of individuals with difficulties in communication and social interaction. Since then, there has been considerable interest and debate surrounding AS. Although AS was introduced as a distinct diagnostic category in the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-4, 1994), its diagnostic label was removed from the subsequent edition, the Diagnostic and Statistical Manual of Mental Disorders (DSM–5), almost two decades later. Instead, AS was incorporated into a broader category known as autism spectrum disorders (ASD). This change reflected a growing recognition that autism encompasses a spectrum of experiences with varying degrees of severity and a wide range of associated characteristics. Autism spectrum disorders (ASD) encompass a range of neurodevelopmental conditions characterized by diverse degrees and manifestations. Typically emerging in early childhood, these disorders are marked by challenges in social communication and interaction and behavioral patterns that involve restricted interests and repetitive behaviors. The changes made to the classification of ASD in DSM-5 sparked controversy regarding the loss of the distinct Asperger identity. This shift in classification continues to be a topic of debate within the literature, as discussions revolve around the formulation and inclusion of AS within the broader ASD framework. Given the extensive historical background of AS, its distinct semiotics, and the relatively characteristic clinical presentations, specialists still utilize this diagnosis as a subtype of ASD characterized by the absence of language delay and a normal or above-average IQ. This topic review will describe the essential aspects of autism spectrum disorder and Asperger syndrome. For greater transparency, the following have been referred to: Asperger syndrome (AS): identified as a subgroup within the category of pervasive developmental disorders (PDD) as per the DSM-4-TR classification. ASD: categorized as a range of neurodevelopmental conditions in the DSM-5. Autism spectrum disorder of an Asperger syndrome type (ASD-AS): is a specific subgroup in the DSM-5 classification of ASD. ASD-AS is characterized by individuals who exhibit symptoms consistent with ASD, specifically at Level 1 severity, without accompanying intellectual impairment. In 1944, approximately one year after psychiatrist Leo Kanner first described infantile autism, Hans Asperger published a case report introducing a condition called "autistic psychopathy."In 1980, the American Psychiatric Association (APA) officially acknowledged autism as a distinct category in the DSM-3, where it was initially presented as "infantile autism." Following that, in 1981, psychiatrist Lorna Wing reignited research on Asperger's work and rebranded "autistic psychopathy" as "Asperger syndrome." A few years later, in 1989, the first diagnostic criteria for Asperger syndrome were proposed. The 10th Revision of the International Classification of Diseases (ICD-10), introduced in 1993, was the first significant classification system to recognize Asperger syndrome (AS). Then, in 1994, AS was formally introduced as a distinct entity in the DSM-4. It was categorized within PDD alongside autism spectrum disorder, marking an important milestone in recognizing and understanding AS as a separate diagnostic category. While during this period, researchers were focused on developing measures to diagnose AS and differentiate it from high-functioning autism (HFA), the DSM-5 removed the diagnostic category of AS in 2013. The World Health Organization (WHO) also followed a similar approach in ICD-11, which came into effect in 2022. The systematic description of psychiatric disorders is complicated, particularly in child and adolescent psychiatry. Asperger Syndrome was included in the DSM-5-TR in the large family of PDD. PDD has five subtypes: Autism spectrum disorder. Asperger syndrome. Childhood disintegrative disorder. Pervasive developmental disorder not otherwise specified (PDD-NOS). Rett syndrome. In DSM-IV-TR, the symptoms and clinical specifiers for autistic disorder within the pervasive developmental disorders (PDD) category fell into three broad categories: social interaction, communication, and restricted and repetitive behavior. The diagnostic criteria for Asperger syndrome (AS) used to include: Individuals exhibiting at least two symptoms of social impairment and at least one symptom each from the category of communication deficits and restricted, repetitive behaviors (RRB). Delayed or impaired functioning in at least one of the following areas: social interaction, language as used in social communication, or symbolic or imaginative play with onset before the age of three years. Individuals who met the diagnostic criteria for autistic disorder (or another specific PDD) would not meet the criteria for AS. In such cases, the diagnosis of autistic disorder would take precedence. AS, as contrasted with autistic disorder, was differentiated based on several key factors, as outlined: Absence of diagnostic criteria in the communication domain. Lack of a requirement for onset before age 3. Addition of criteria specifying the absence of a language delay. Addition of criteria specifying the absence of a deficit in cognitive development. This classification proposed a differential diagnosis between AS and high-functioning autism (HFA), a type of autistic disorder characterized by normal cognitive functioning. The differential diagnosis between AS and HFA sparked significant debate due to uncertainties in defining the specific criteria for AS and the clinical overlap between the two conditions. This debate is reflected in the literature, which has produced contradictory results regarding the distinctiveness of AS and HFA. While research has identified nuanced differences between the two disorders, most studies have emphasized the similarities between AS and HFA. Ultimately, the DSM-5 removed PDD and its categorization and merged four subtypes into one category with a continuum named autistic spectrum disorders (ASD). This significant alteration was due to the assumption that PDD subgroups cannot be differentiated from one another certainly and reliably. As a result, several changes were made in the classification system, including the following: Elimination of PDD and its subtypes. Creation of a new diagnostic category called autistic spectrum disorders (ASD), encompassing autistic disorder, Asperger syndrome, childhood disintegrative disorder, and PDD-NOS. Addition of three levels of severity for ASD. These severity levels help provide a more comprehensive understanding of the individual's functional impairments and support needs. Shifting from the previous PDD classification, which consisted of 3 domains, to the ASD classification, which comprises 3 domains. These 2 domains encompass: 1. Impaired social communication and interaction. 2. RRB, interests, and activities. Addition of sensory symptoms in the RRB component of diagnostic criteria. Changing the specification of the age of onset from age 3 to "early childhood.". Creation of a new diagnostic category called "social communication disorder" (SCD) to include individuals with difficulties in social communication and interaction but who do not meet RRB criteria found in ASD. Removal of Rett syndrome from the classification based on recent genetic data. Including social communication and interaction-related deficits in one criterion while excluding the deficit related to spoken language. The new classification has faced criticism in the literature, with some authors suggesting that it may lead to narrower criteria for ASD. As a result, there is concern that certain individuals, particularly those who are cognitively able or previously diagnosed with AS or PDD-NOS (pervasive developmental disorder not otherwise specified), may no longer meet the criteria for an ASD diagnosis. In summary, the main argument is that while the reduced sensitivity of the new ASD classification may increase specificity, it can have negative implications for service eligibility and the ability of researchers to integrate information and data from studies conducted under these criteria. On the other hand, some authors argue that eliminating the specific diagnostic category for AS may lead to increased stigma toward individuals previously diagnosed with AS. This argument is based on the assumption that societies with a negative perception of autism as a significant disability may stigmatize individuals falling under the ASD umbrella. In contrast, AS has been associated with more positive stereotypes, and its removal as a separate category could potentially contribute to losing those positive associations. Thus, the new inclusion of AS in the category of ASD may have a negative effect on the identity of the individuals who have adopted this label as an identity. However, the literature on the potential impact of the DSM-5 changes on individuals previously diagnosed with AS is limited. The results of the discussions surrounding the changes in the ASD classification can be categorized into three groups: those who support the changes, those who oppose the changes, and those who express mixed feelings about the changes.

摘要

阿斯伯格综合征(AS)于1944年由汉斯·阿斯伯格首次描述,是指在沟通和社交互动方面存在困难的个体的行为特征。从那时起,围绕阿斯伯格综合征产生了大量的关注和争论。尽管阿斯伯格综合征在《精神疾病诊断与统计手册》第四版(DSM - 4,1994)中被引入作为一个独立的诊断类别,但近二十年后,其诊断标签在后续版本《精神疾病诊断与统计手册》(DSM - 5)中被删除。取而代之的是,阿斯伯格综合征被纳入一个更广泛的类别,即自闭症谱系障碍(ASD)。这一变化反映了人们越来越认识到自闭症涵盖了一系列严重程度不同且具有广泛相关特征的经历。自闭症谱系障碍(ASD)包括一系列神经发育状况,其特征是程度和表现各不相同。这些障碍通常在幼儿期出现,其特征是社交沟通和互动方面存在挑战,以及涉及兴趣受限和重复行为的行为模式。DSM - 5中对ASD分类的改变引发了关于阿斯伯格综合征独特身份丧失的争议。这种分类转变在文献中仍然是一个争论的话题,因为讨论围绕着在更广泛的ASD框架内阿斯伯格综合征的形成和纳入。鉴于阿斯伯格综合征广泛的历史背景、其独特的符号学以及相对典型的临床表现,专家们仍然将这一诊断用作ASD的一个亚型,其特征是没有语言发育迟缓且智商正常或高于平均水平。本专题综述将描述自闭症谱系障碍和阿斯伯格综合征的基本方面。为了提高透明度,参考了以下内容:阿斯伯格综合征(AS):根据DSM - 4 - TR分类,被确定为广泛性发育障碍(PDD)类别中的一个亚组。ASD:在DSM - 5中被归类为一系列神经发育状况。阿斯伯格综合征类型的自闭症谱系障碍(ASD - AS):是DSM - 5中ASD分类的一个特定亚组。ASD - AS的特征是个体表现出与ASD一致的症状,特别是在1级严重程度,且没有智力障碍。1944年,在精神科医生利奥·坎纳首次描述婴儿自闭症大约一年后,汉斯·阿斯伯格发表了一篇病例报告,介绍了一种名为“自闭性精神病”的病症。1980年,美国精神病学协会(APA)在DSM - 3中正式承认自闭症是一个独立的类别,最初将其表述为“婴儿自闭症”。随后,在1981年,精神科医生洛娜·温重新点燃了对阿斯伯格研究工作的研究,并将“自闭性精神病”重新命名为“阿斯伯格综合征”。几年后的1989年,首次提出了阿斯伯格综合征的诊断标准。1993年引入的《国际疾病分类第10版》(ICD - 10)是第一个承认阿斯伯格综合征(AS)的重要分类系统。然后,在1994年,AS在DSM - 4中被正式引入作为一个独立的实体。它与自闭症谱系障碍一起被归类在PDD中,这标志着将AS识别和理解为一个单独诊断类别的一个重要里程碑。在此期间,研究人员专注于开发诊断AS的方法,并将其与高功能自闭症(HFA)区分开来,而DSM - 5在2013年取消了AS的诊断类别。世界卫生组织(WHO)在2022年生效的ICD - 11中也采取了类似的方法。精神疾病的系统描述很复杂,特别是在儿童和青少年精神病学中。阿斯伯格综合征被纳入了DSM - 5 - TR中的PDD大家庭。PDD有五个亚型:自闭症谱系障碍、阿斯伯格综合征、儿童期崩解症、未特定的广泛性发育障碍(PDD - NOS)、雷特综合征。在DSM - IV - TR中,广泛性发育障碍(PDD)类别中自闭症障碍的症状和临床说明分为三大类:社交互动、沟通以及受限和重复行为。阿斯伯格综合征(AS)的诊断标准过去包括:个体表现出至少两种社交障碍症状,以及沟通缺陷和受限、重复行为(RRB)类别中各至少一种症状。在以下至少一个领域存在功能延迟或受损:社交互动、社交沟通中使用的语言,或三岁前开始的象征性或想象性游戏。符合自闭症障碍(或另一种特定PDD)诊断标准的个体不符合AS的标准。在这种情况下,自闭症障碍的诊断将优先。与自闭症障碍相比,AS是基于几个关键因素进行区分的,如下所述:沟通领域没有诊断标准。不要求在3岁前发病。增加了明确无语言延迟的标准。增加了明确无认知发展缺陷的标准。这种分类提出了AS与高功能自闭症(HFA)之间的鉴别诊断,HFA是一种以正常认知功能为特征的自闭症障碍类型。AS与HFA之间的鉴别诊断引发了重大争议,因为在定义AS的具体标准以及这两种情况之间的临床重叠方面存在不确定性。这场争论反映在文献中,关于AS和HFA的独特性产生了相互矛盾的结果。虽然研究已经确定了这两种障碍之间的细微差别,但大多数研究都强调了AS和HFA之间的相似性。最终,DSM - 5取消了PDD及其分类,并将四个亚型合并为一个类别,称为自闭症谱系障碍(ASD),具有一个连续体。这一重大改变是由于假设PDD亚组不能肯定且可靠地相互区分。因此,在分类系统中进行了一些更改,包括以下内容:取消PDD及其亚型。创建一个新的诊断类别,称为自闭症谱系障碍(ASD),包括自闭症障碍、阿斯伯格综合征、儿童期崩解症和PDD - NOS。为ASD增加了三个严重程度级别。这些严重程度级别有助于更全面地了解个体的功能损害和支持需求。从以前由3个领域组成的PDD分类转变为ASD分类,ASD分类由2个领域组成。这2个领域包括:1. 社交沟通和互动受损。2. RRB、兴趣和活动。在诊断标准的RRB部分增加了感觉症状。将发病年龄的说明从3岁改为“幼儿期”。创建一个新的诊断类别,称为“社交沟通障碍”(SCD),以包括在社交沟通和互动方面有困难但不符合ASD中RRB标准的个体。根据最近的基因数据,从分类中删除了雷特综合征。在一个标准中包括与社交沟通和互动相关的缺陷,同时排除与口语相关的缺陷。新的分类在文献中受到了批评,一些作者认为这可能导致ASD的标准变窄。因此,有人担心某些个体,特别是那些认知能力较强或以前被诊断为患有AS或PDD - NOS(未特定的广泛性发育障碍)的个体,可能不再符合ASD诊断的标准。总之,主要的论点是,虽然新的ASD分类的敏感性降低可能会提高特异性,但它可能对服务资格以及研究人员整合根据这些标准进行的研究中的信息和数据的能力产生负面影响。另一方面,一些作者认为取消AS的特定诊断类别可能会增加对以前被诊断为患有AS的个体的污名化。这一论点基于这样的假设,即对自闭症持负面看法认为其是一种严重残疾的社会可能会污名化属于ASD范畴的个体。相比之下,AS与更积极的刻板印象相关联,将其作为一个单独类别删除可能会导致失去这些积极的关联。因此,将AS新纳入ASD类别可能会对那些采用这个标签作为身份认同的个体的身份产生负面影响。然而,关于DSM - 5变化对以前被诊断为患有AS的个体的潜在影响的文献有限。围绕ASD分类变化的讨论结果可分为三组:支持这些变化的人、反对这些变化的人以及对这些变化表达复杂感受的人。

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