Watanabe K, Kishida K, Haneda N, Horino N, Nishio T, Mori C
Department of Pediatrics, Shimane Medical University.
J Cardiol. 1988 Jun;18(2):451-6.
The correlation of left ventricular end-systolic wall stress (ESS) with the mean velocity of fiber shortening (mVcf) is an index of the myocardial contractile state, independent of the ventricular loading conditions (afterload). However, there have been few reported estimates of the effect of changes in the heart rate on the ESS-mVcf relationship. In the present study, 25 subjects with histories of Kawasaki disease (mucocutaneous lymph node syndrome: MCLS) were evaluated for the effects of changes in heart rate, afterload and preload, on the ESS-mVcf relationship. The latter was independent of afterload. After atrial pacing, ESS decreased and mVcf increased, both significantly, compared to those of subjects at rest. The change of the ESS-mVcf relationship induced by atrial pacing approximately paralleled the mean regression line obtained in the resting state. However, the shift induced by preload was not parallel to the mean regression line for the resting population. These data suggest that the ESS-mVcf relationship is independent of any change in heart rate, and that it may depend on preload.
左心室收缩末期壁应力（ESS）与心肌纤维缩短平均速度（mVcf）之间的相关性是心肌收缩状态的一个指标，独立于心室负荷条件（后负荷）。然而，关于心率变化对ESS-mVcf关系影响的报道估计很少。在本研究中，对25名有川崎病（黏膜皮肤淋巴结综合征：MCLS）病史的受试者进行了评估，以探讨心率、后负荷和前负荷变化对ESS-mVcf关系的影响。后者独立于后负荷。心房起搏后，与静息状态下的受试者相比，ESS显著降低，mVcf显著增加。心房起搏引起的ESS-mVcf关系变化大致与静息状态下获得的平均回归线平行。然而，前负荷引起的偏移与静息人群的平均回归线不平行。这些数据表明，ESS-mVcf关系独立于心率的任何变化，并且可能取决于前负荷。
