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对《MitoVitE、α-生育酚和曲洛昔芬对在模拟脓毒症条件下培养的内皮细胞氧化应激、线粒体功能及炎症信号通路的差异影响。2020年,(3),195》评论的回复

Reply to Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis. 2020, (3), 195".

作者信息

Minter Beverley E, Lowes Damon A, Webster Nigel R, Galley Helen F

机构信息

Institute of Medical Sciences, University of Aberdeen, Aberdeen AB41 8TJ, UK.

出版信息

Antioxidants (Basel). 2020 Jun 1;9(6):464. doi: 10.3390/antiox9060464.

DOI:10.3390/antiox9060464
PMID:32492782
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7346183/
Abstract

We thank Drs Hegarty and Byrne for their interest in our paper and appreciate the opportunity to respond to their insightful comments [...].

摘要

我们感谢赫加蒂博士和伯恩博士对我们论文的关注,并感谢有机会回应他们深刻的评论[……]。

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Reply to Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis. 2020, (3), 195".对《MitoVitE、α-生育酚和曲洛昔芬对在模拟脓毒症条件下培养的内皮细胞氧化应激、线粒体功能及炎症信号通路的差异影响。2020年,(3),195》评论的回复
Antioxidants (Basel). 2020 Jun 1;9(6):464. doi: 10.3390/antiox9060464.
2
Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis 2020, (3), 195".关于《MitoVitE、α-生育酚和曲克芦丁对在模拟脓毒症条件下培养的内皮细胞中氧化应激、线粒体功能和炎症信号通路的不同影响》(2020年,第3期,第195页)的评论
Antioxidants (Basel). 2020 May 29;9(6):462. doi: 10.3390/antiox9060462.
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Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis.米托维生素E、α-生育酚和曲洛昔芬对在模拟脓毒症条件下培养的内皮细胞氧化应激、线粒体功能及炎症信号通路的不同影响
Antioxidants (Basel). 2020 Feb 26;9(3):195. doi: 10.3390/antiox9030195.
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MitoVitE, a mitochondria-targeted antioxidant, limits paclitaxel-induced oxidative stress and mitochondrial damage in vitro, and paclitaxel-induced mechanical hypersensitivity in a rat pain model.MitoVitE,一种靶向线粒体的抗氧化剂,可减少紫杉醇诱导的体外氧化应激和线粒体损伤,并减轻紫杉醇诱导的大鼠疼痛模型中的机械性痛觉过敏。
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Pharmacological activation of endogenous protective pathways against oxidative stress under conditions of sepsis.脓毒症状态下,通过药物激活内源性抗氧化应激保护途径。
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alpha-Tocopherol and trolox block the early intracellular events (TBARS and calcium rises) elicited by oxidized low density lipoproteins in cultured endothelial cells.α-生育酚和生育三烯酚可阻断培养的内皮细胞中由氧化型低密度脂蛋白引发的早期细胞内事件(丙二醛生成和钙升高)。
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Renoprotective effect of trolox against ischaemia-reperfusion injury in rats.生育三烯酚对大鼠缺血再灌注损伤的肾脏保护作用。
Clin Exp Pharmacol Physiol. 2007 Aug;34(8):753-9. doi: 10.1111/j.1440-1681.2007.04651.x.
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Alpha-tocopherol amplifies phosphorylation of endothelial nitric oxide synthase at serine 1177 and its short-chain derivative trolox stabilizes tetrahydrobiopterin.α-生育酚可增强内皮型一氧化氮合酶在丝氨酸1177位点的磷酸化,其短链衍生物生育三烯酚可稳定四氢生物蝶呤。
Free Radic Biol Med. 2004 Sep 1;37(5):620-31. doi: 10.1016/j.freeradbiomed.2004.05.017.
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Protective Effects of α-Tocopherol, γ-Tocopherol and Oleic Acid, Three Compounds of Olive Oils, and No Effect of Trolox, on 7-Ketocholesterol-Induced Mitochondrial and Peroxisomal Dysfunction in Microglial BV-2 Cells.橄榄油中的三种化合物α-生育酚、γ-生育酚和油酸的保护作用,以及托可索仑对7-酮胆固醇诱导的小胶质细胞BV-2线粒体和过氧化物酶体功能障碍无影响。
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Low zinc and selenium concentrations in sepsis are associated with oxidative damage and inflammation.脓毒症中锌和硒浓度较低与氧化损伤及炎症相关。
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本文引用的文献

1
Comment on "Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis 2020, (3), 195".关于《MitoVitE、α-生育酚和曲克芦丁对在模拟脓毒症条件下培养的内皮细胞中氧化应激、线粒体功能和炎症信号通路的不同影响》(2020年,第3期,第195页)的评论
Antioxidants (Basel). 2020 May 29;9(6):462. doi: 10.3390/antiox9060462.
2
Differential Effects of MitoVitE, α-Tocopherol and Trolox on Oxidative Stress, Mitochondrial Function and Inflammatory Signalling Pathways in Endothelial Cells Cultured under Conditions Mimicking Sepsis.米托维生素E、α-生育酚和曲洛昔芬对在模拟脓毒症条件下培养的内皮细胞氧化应激、线粒体功能及炎症信号通路的不同影响
Antioxidants (Basel). 2020 Feb 26;9(3):195. doi: 10.3390/antiox9030195.
3
Small Molecule Interferences in Resazurin and MTT-Based Metabolic Assays in the Absence of Cells.小分子在无细胞状态下对 Resazurin 和 MTT 代谢测定的干扰。
Anal Chem. 2018 Jun 5;90(11):6867-6876. doi: 10.1021/acs.analchem.8b01043. Epub 2018 May 17.