早期发育阶段电离辐射的特定效应。
Stage-Specific Effects of Ionizing Radiation during Early Development.
机构信息
Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine (RIRBM), Hiroshima University, Hiroshima 734-8553, Japan.
出版信息
Int J Mol Sci. 2020 Jun 1;21(11):3975. doi: 10.3390/ijms21113975.
Abstract
Early embryonic cells are sensitive to genotoxic stressors such as ionizing radiation. However, sensitivity to these stressors varies depending on the embryonic stage. Recently, the sensitivity and response to ionizing radiation were found to differ during the preimplantation period. The cellular and molecular mechanisms underlying the change during this period are beginning to be elucidated. In this review, we focus on the changes in radio-sensitivity and responses to ionizing radiation during the early developmental stages of the preimplantation (before gastrulation) period in mammals, , and fish. Furthermore, we discuss the underlying cellular and molecular mechanisms and the similarities and differences between species.
摘要
早期胚胎细胞对遗传毒性应激因子（如电离辐射）敏感。然而，对这些应激因子的敏感性取决于胚胎阶段。最近，人们发现，在着床前阶段，细胞对电离辐射的敏感性和反应存在差异。在此期间，变化背后的细胞和分子机制开始被阐明。在这篇综述中，我们专注于哺乳动物和鱼类着床前（原肠胚形成之前）早期发育阶段对电离辐射的敏感性和反应的变化。此外，我们还讨论了潜在的细胞和分子机制以及种间的异同。
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