Division of Biological Science, Nara Institute of Science and Technology, 8916-5 Takayama-cho, Ikoma-shi, Nara 630-0192, Japan.
Cells. 2020 Jun 1;9(6):1376. doi: 10.3390/cells9061376.
On December 10, 2018, I was sitting among the big crowd of audience, as one of the invited guests to the ceremony, in the Stockholm Concert Hall. When King of Sweden Carl XVI Gustaf bestowed the diploma and medal of Nobel Prize of Physiology or Medicine 2018 on Dr. Tasuku Honjo and shook his hand for a while, surrounded by the thunderous applause and energetically blessing orchestral music, I thought that it had been a long journey for the molecule that we had first isolated in the early 1990s. Although it was truly a commemorable moment in the history of the programmed death-1 (PD-1) research, I believe we still have a long way to go. In this review article, I will explain why I think so, particularly by focusing on the potential role(s) that PD-1 appears to play in self-nonself discrimination by the immune system.
2018 年 12 月 10 日，我作为受邀嘉宾之一，坐在斯德哥尔摩音乐厅的一大群观众中。当瑞典国王卡尔十六世·古斯塔夫向本庶佑博士授予 2018 年诺贝尔生理学或医学奖的证书和奖章，并与他握手时，周围是雷鸣般的掌声和充满活力的祝福管弦乐，我想，我们在 20 世纪 90 年代初首次分离出的这种分子已经走过了漫长的道路。尽管这确实是 PD-1 研究史上值得纪念的时刻，但我相信我们还有很长的路要走。在这篇综述文章中，我将解释为什么我会这样认为，特别是通过关注 PD-1 在免疫系统的自我非我识别中所扮演的潜在角色。
