Department of Nephrology and Immunology, Children's Hospital of Soochow University, Suzhou, Jiangsu, China.
Front Immunol. 2024 Oct 23;15:1458209. doi: 10.3389/fimmu.2024.1458209. eCollection 2024.
In recent years, knowledge regarding immune regulation has expanded rapidly, and major advancements have been made in immunotherapy for immune-associated disorders, particularly cancer. The programmed cell death 1 (PD-1) pathway is a cornerstone in immune regulation. It comprises PD-1 and its ligands mediating immune tolerance mechanisms and immune homeostasis. Accumulating evidence demonstrates that the PD-1 axis has a crucial immunosuppressive role in the tumor microenvironment and autoimmune diseases. PD-1 receptors and ligands on immune cells and renal parenchymal cells aid in maintaining immunological homeostasis in the kidneys. Here, we present a comprehensive review of PD-1 immunology in various kidney disorders, including renal cell carcinoma, glomerulonephritis, kidney transplantation, renal aging, and renal immune-related adverse events secondary to PD-1 immunotherapy.
近年来，人们对免疫调节的认识迅速扩展，免疫疗法在治疗免疫相关疾病方面，尤其是癌症方面取得了重大进展。程序性细胞死亡蛋白 1（PD-1）通路是免疫调节的基石。它由 PD-1 及其配体介导免疫耐受机制和免疫稳态。越来越多的证据表明，PD-1 轴在肿瘤微环境和自身免疫性疾病中具有重要的免疫抑制作用。免疫细胞和肾实质细胞上的 PD-1 受体和配体有助于维持肾脏的免疫稳态。在这里，我们全面回顾了 PD-1 在各种肾脏疾病中的免疫学作用，包括肾细胞癌、肾小球肾炎、肾移植、肾脏衰老以及 PD-1 免疫治疗引起的肾脏免疫相关不良事件。
