Nerkar D P, Govekar L G, Kumta U S, Sreenivasan A
Int J Radiat Biol Relat Stud Phys Chem Med. 1977 Apr;31(4):335-40. doi: 10.1080/09553007714550391.
Gamma-irradiation of S. typhimurium cells up to a dose of 500 krad significantly reduces their toxicity. However, the antigenicity of these cells is not altered, which suggests that these cells could be used as a vaccine. The protection offered by the irradiated cells is comparable to that of formalin-treated cells. The radio-vaccine, however, offers an additional advantage of significant detoxification of the endotoxin, thereby minimizing side effects. The lipopolysaccharide extracted from the irradiated S. typhimurium cells offered cross-protection against other Salmonella species tested.
对鼠伤寒沙门氏菌细胞进行高达500千拉德剂量的伽马辐射，可显著降低其毒性。然而，这些细胞的抗原性并未改变，这表明这些细胞可用作疫苗。辐照后的细胞所提供的保护作用与经福尔马林处理的细胞相当。不过，辐射疫苗还有一个额外的优势，即能对内毒素进行显著解毒，从而将副作用降至最低。从辐照后的鼠伤寒沙门氏菌细胞中提取的脂多糖对所测试的其他沙门氏菌菌株具有交叉保护作用。
