LabTAU, INSERM, Centre Léon Bérard, Université Lyon 1, Univ Lyon, Lyon, France.
LabTAU, INSERM, Centre Léon Bérard, Université Lyon 1, Univ Lyon, Lyon, France.
Ultrasound Med Biol. 2020 Aug;46(8):1968-1977. doi: 10.1016/j.ultrasmedbio.2020.03.019. Epub 2020 Jun 1.
High-intensity focused ultrasound is a non-invasive modality for thermal ablation of tissues through locally increased temperature. Thermal lesions can be monitored by elastography, following the changes in the elastic properties of the tissue as reflected by the shear-wave velocity. Most studies on ultrasound elastography use shear waves created by acoustic radiation force. However, in the human body, the natural noise resulting from cardiac activity or arterial pulsatility can be used to characterize elasticity through noise-correlation techniques, in the method known as passive elastography. The objective of this study was to investigate the feasibility of monitoring high-intensity ultrasound treatments of liver tissue using passive elastography. Bovine livers were heated to 80°C using a high-intensity planar transducer and imaged with a high-frame-rate ultrasound imaging device. The dynamics of lesion formation are captured through tissue stiffening and lesion expansion.
高强度聚焦超声是一种通过局部升温来实现组织热消融的非侵入性方法。弹性成像是通过剪切波速度反映组织弹性特性的变化来监测热损伤的。大多数超声弹性成像研究都使用声辐射力产生的剪切波。然而，在人体中，可以利用源自心脏活动或动脉搏动的自然噪声，通过噪声相关技术来对弹性进行特征描述，这种方法称为被动弹性成像。本研究旨在探讨使用被动弹性成像监测高强度超声治疗肝脏组织的可行性。使用高强度平面换能器将牛肝加热至 80°C，并使用高帧率超声成像设备进行成像。通过组织变硬和损伤扩大来捕获损伤形成的动力学。
