小唾液腺分泌癌的临床病理研究：4 例系列病例和诊断要点。
A clinicopathologic study of secretory carcinoma of minor salivary gland: a series of 4 cases and diagnostic considerations.
机构信息
Missouri School of Dentistry and Oral Health, A.T. Still University, Kirksville, MO, USA.
Joint Base San Antonio-Lackland Air Force Base, San Antonio, TX, USA.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2021 Apr;131(4):463-467. doi: 10.1016/j.oooo.2020.04.001. Epub 2020 May 31.
OBJECTIVE
Secretory carcinoma (SC) of salivary gland is a recently described low-grade malignant neoplasm of the salivary gland, characterized by rearrangement of the ETV6 gene. SC of salivary gland shares striking morphologic, immunophenotypic, and molecular similarity to SC of breast.
STUDY DESIGN
We report the clinicopathologic features of 4 ETV6-rearranged SCs of minor salivary gland and histopathologic diagnostic considerations.
RESULTS
Two cases were located in the lip, 1 in the soft palate, and 1 in the mandibular vestibule. No patient presented with regional or distant metastases at diagnosis. All cases were positive for S100 protein and mammaglobin, and all cases were negative for p63. All cases were positive for ETV6 rearrangement.
CONCLUSIONS
SC of the minor salivary glands are rare. Because of its shared histopathologic features with other salivary gland tumors, positivity for ETV6 gene rearrangements is recommended before rendering a diagnosis of SC of salivary gland.
目的
涎腺分泌性癌（SC）是一种新近描述的涎腺低度恶性肿瘤，其特征在于 ETV6 基因的重排。涎腺 SC 与乳腺 SC 在形态、免疫表型和分子水平上具有显著的相似性。
研究设计
我们报告了 4 例 ETV6 重排的小涎腺癌的临床病理特征和组织病理学诊断注意事项。
结果
2 例位于唇，1 例位于软腭，1 例位于下颌前庭。诊断时无患者出现区域性或远处转移。所有病例均对 S100 蛋白和乳球蛋白呈阳性，均对 p63 呈阴性。所有病例均为 ETV6 重排阳性。
结论
小涎腺的 SC 较为罕见。由于其与其他涎腺肿瘤具有共同的组织病理学特征，在诊断涎腺 SC 之前，建议进行 ETV6 基因重排的阳性检测。
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