Centre for Research in Diabetes, Metabolism and Nutrition, II. Department of Medicine, Faculty Hospital Kralovske Vinohrady nad 3rd Faculty of Medicine, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.
Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic.
Arch Gynecol Obstet. 2020 Aug;302(2):305-314. doi: 10.1007/s00404-020-05626-y. Epub 2020 Jun 3.
Screening of gestational diabetes/GDM (although different in different countries) represents a standard procedure allowing to identify women with pregnancy-associated diabetes. Some of the women with GDM (up to 5%) may, however, suffer from previously undiagnosed MODY (Maturity-Onset Diabetes of the Young). Currently, no international or local guidelines focused on the identification of MODY among GDM exist. Thus, the aim of this manuscript is to propose a clear guide for clinicians on how to detect MODY among pregnant women with gestational diabetes.
Based on the available literature about diagnosis (in general population) of MODY and management of MODY (both, in general population and in pregnant women), we propose a clear clinical guide on how to diagnose and manage MODY in pregnancy.
The manuscript suggests a feasible clinical approach how to recognize MODY among patients with GDM and how to manage pregnancy of women with three most common MODY subtypes.
A correct classification of diabetes is, nonetheless, essential, particularly in case of MODY, as the management of pregnant women with MODY is different and the correct diagnosis of MODY enables individualized treatment with regard to optimal pregnancy outcomes.
尽管不同国家的具体方法有所不同,但妊娠期糖尿病/ GDM 的筛查是一种标准程序,可用于识别与妊娠相关的糖尿病女性。然而,一些 GDM 女性(高达 5%)可能患有先前未确诊的 MODY(年轻起病的成年型糖尿病)。目前,尚无针对 GDM 中 MODY 识别的国际或本地指南。因此,本文的目的是为临床医生提供一个明确的指导,说明如何在患有妊娠糖尿病的孕妇中检测 MODY。
根据现有的关于 MODY 诊断(一般人群)和 MODY 管理(一般人群和孕妇)的文献,我们提出了一个明确的临床指南,说明如何在怀孕期间诊断和管理 MODY。
本文提出了一种可行的临床方法,用于识别 GDM 患者中的 MODY,以及如何管理三种最常见 MODY 亚型的孕妇的妊娠。
正确分类糖尿病是至关重要的,特别是对于 MODY 而言,因为 MODY 孕妇的管理方式不同,正确诊断 MODY 可以实现个体化治疗,以获得最佳妊娠结局。