• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

妊娠期糖尿病筛查患者中 MODY 的鉴定:临床医生指南。

Identification of MODY among patients screened for gestational diabetes: a clinician's guide.

机构信息

Centre for Research in Diabetes, Metabolism and Nutrition, II. Department of Medicine, Faculty Hospital Kralovske Vinohrady nad 3rd Faculty of Medicine, Charles University, Šrobárova 50, 100 34, Prague 10, Czech Republic.

Department of Internal Medicine, Second Faculty of Medicine, Charles University, Prague, Czech Republic.

出版信息

Arch Gynecol Obstet. 2020 Aug;302(2):305-314. doi: 10.1007/s00404-020-05626-y. Epub 2020 Jun 3.

DOI:10.1007/s00404-020-05626-y
PMID:32495018
Abstract

PURPOSE

Screening of gestational diabetes/GDM (although different in different countries) represents a standard procedure allowing to identify women with pregnancy-associated diabetes. Some of the women with GDM (up to 5%) may, however, suffer from previously undiagnosed MODY (Maturity-Onset Diabetes of the Young). Currently, no international or local guidelines focused on the identification of MODY among GDM exist. Thus, the aim of this manuscript is to propose a clear guide for clinicians on how to detect MODY among pregnant women with gestational diabetes.

METHODS

Based on the available literature about diagnosis (in general population) of MODY and management of MODY (both, in general population and in pregnant women), we propose a clear clinical guide on how to diagnose and manage MODY in pregnancy.

RESULTS

The manuscript suggests a feasible clinical approach how to recognize MODY among patients with GDM and how to manage pregnancy of women with three most common MODY subtypes.

CONCLUSION

A correct classification of diabetes is, nonetheless, essential, particularly in case of MODY, as the management of pregnant women with MODY is different and the correct diagnosis of MODY enables individualized treatment with regard to optimal pregnancy outcomes.

摘要

目的

尽管不同国家的具体方法有所不同,但妊娠期糖尿病/ GDM 的筛查是一种标准程序,可用于识别与妊娠相关的糖尿病女性。然而,一些 GDM 女性(高达 5%)可能患有先前未确诊的 MODY(年轻起病的成年型糖尿病)。目前,尚无针对 GDM 中 MODY 识别的国际或本地指南。因此,本文的目的是为临床医生提供一个明确的指导,说明如何在患有妊娠糖尿病的孕妇中检测 MODY。

方法

根据现有的关于 MODY 诊断(一般人群)和 MODY 管理(一般人群和孕妇)的文献,我们提出了一个明确的临床指南,说明如何在怀孕期间诊断和管理 MODY。

结果

本文提出了一种可行的临床方法,用于识别 GDM 患者中的 MODY,以及如何管理三种最常见 MODY 亚型的孕妇的妊娠。

结论

正确分类糖尿病是至关重要的,特别是对于 MODY 而言,因为 MODY 孕妇的管理方式不同,正确诊断 MODY 可以实现个体化治疗,以获得最佳妊娠结局。

相似文献

1
Identification of MODY among patients screened for gestational diabetes: a clinician's guide.妊娠期糖尿病筛查患者中 MODY 的鉴定:临床医生指南。
Arch Gynecol Obstet. 2020 Aug;302(2):305-314. doi: 10.1007/s00404-020-05626-y. Epub 2020 Jun 3.
2
The 0.1% of the population with glucokinase monogenic diabetes can be recognized by clinical characteristics in pregnancy: the Atlantic Diabetes in Pregnancy cohort.在妊娠期间,通过临床特征可以识别出患有葡萄糖激酶单基因糖尿病的人群,占总人口的 0.1%:大西洋妊娠糖尿病队列研究。
Diabetes Care. 2014;37(5):1230-6. doi: 10.2337/dc13-2248. Epub 2014 Feb 18.
3
Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c.在一个多民族妊娠糖尿病队列中识别葡萄糖激酶单基因糖尿病:新的妊娠筛查标准和 HbA1c 的效用。
Diabetes Care. 2016 Jan;39(1):50-2. doi: 10.2337/dc15-1001. Epub 2015 Jun 24.
4
MODY diabetes and screening of gestational diabetes.青少年发病的成年型糖尿病与妊娠期糖尿病筛查
Ceska Gynekol. 2020 Winter;85(2):124-130.
5
Glucokinase Deficit Prevalence in Women With Diabetes in Pregnancy: A Matter of Screening Selection.妊娠期糖尿病患者中葡萄糖激酶缺陷的流行情况:筛查选择的问题。
Front Endocrinol (Lausanne). 2020 May 20;11:268. doi: 10.3389/fendo.2020.00268. eCollection 2020.
6
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds.GCK单基因糖尿病与妊娠期糖尿病:基于临床依据的可能诊断
Diabet Med. 2015 Dec;32(12):1596-601. doi: 10.1111/dme.12830. Epub 2015 Jul 2.
7
Monogenic diabetes caused by GCK gene mutation is misdiagnosed as gestational diabetes - A multicenter study in Portugal.由GCK基因突变引起的单基因糖尿病被误诊为妊娠期糖尿病——葡萄牙的一项多中心研究
Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102259. doi: 10.1016/j.dsx.2021.102259. Epub 2021 Aug 21.
8
Pregnancy in Women With Monogenic Diabetes due to Pathogenic Variants of the Glucokinase Gene: Lessons and Challenges.致女性单基因糖尿病患者的妊娠相关问题:病因与挑战。
Front Endocrinol (Lausanne). 2022 Jan 5;12:802423. doi: 10.3389/fendo.2021.802423. eCollection 2021.
9
Identification and management of GCK-MODY complicating pregnancy in Chinese patients with gestational diabetes.中国妊娠糖尿病患者 GCK-MODY 的鉴定和管理。
Mol Cell Biochem. 2022 May;477(5):1629-1643. doi: 10.1007/s11010-022-04374-8. Epub 2022 Feb 28.
10
Genetic causes of maturity onset diabetes of the young may be less prevalent in American pregnant women recently diagnosed with diabetes mellitus than in previously studied European populations.与之前研究的欧洲人群相比,近期被诊断为糖尿病的美国孕妇中,青年发病型糖尿病的遗传病因可能没那么普遍。
J Matern Fetal Neonatal Med. 2015 Jul;28(10):1113-5. doi: 10.3109/14767058.2014.944157. Epub 2014 Jul 30.

引用本文的文献

1
Neonatal hypoglycaemia in the offsprings of parents with maturity-onset diabetes of the young (MODY).父母患有青年发病型成年糖尿病(MODY)的后代中的新生儿低血糖症。
J Pediatr Endocrinol Metab. 2025 Apr 28;38(6):570-576. doi: 10.1515/jpem-2025-0042. Print 2025 Jun 26.
2
Monogenic diabetes.单基因糖尿病。
Nat Rev Dis Primers. 2023 Mar 9;9(1):12. doi: 10.1038/s41572-023-00421-w.
3
A Clinical Update on Gestational Diabetes Mellitus.妊娠期糖尿病的临床新进展。

本文引用的文献

1
The impact of diagnostic criteria for gestational diabetes on its prevalence: a systematic review and meta-analysis.妊娠期糖尿病诊断标准对其患病率的影响:一项系统评价和荟萃分析。
Diabetol Metab Syndr. 2019 Feb 1;11:11. doi: 10.1186/s13098-019-0406-1. eCollection 2019.
2
High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus.丹麦妊娠期糖尿病女性中MODY基因糖尿病易感变异的高流行率。
J Endocr Soc. 2017 Apr 27;1(6):681-690. doi: 10.1210/js.2017-00040. eCollection 2017 Jun 1.
3
The Genetic Architecture of Diabetes in Pregnancy: Implications for Clinical Practice.
Endocr Rev. 2022 Sep 26;43(5):763-793. doi: 10.1210/endrev/bnac003.
妊娠期糖尿病的遗传结构:对临床实践的启示。
Am J Perinatol. 2016 Nov;33(13):1319-1326. doi: 10.1055/s-0036-1592078. Epub 2016 Aug 29.
4
Monogenic diabetes and pregnancy.单基因糖尿病与妊娠
Obstet Med. 2015 Sep;8(3):114-20. doi: 10.1177/1753495X15590713. Epub 2015 Jun 29.
5
Identifying Glucokinase Monogenic Diabetes in a Multiethnic Gestational Diabetes Mellitus Cohort: New Pregnancy Screening Criteria and Utility of HbA1c.在一个多民族妊娠糖尿病队列中识别葡萄糖激酶单基因糖尿病:新的妊娠筛查标准和 HbA1c 的效用。
Diabetes Care. 2016 Jan;39(1):50-2. doi: 10.2337/dc15-1001. Epub 2015 Jun 24.
6
GCK monogenic diabetes and gestational diabetes: possible diagnosis on clinical grounds.GCK单基因糖尿病与妊娠期糖尿病:基于临床依据的可能诊断
Diabet Med. 2015 Dec;32(12):1596-601. doi: 10.1111/dme.12830. Epub 2015 Jul 2.
7
HNF1A mutation presenting with fetal macrosomia and hypoglycemia in childhood prior to onset of overt diabetes.
J Pediatr Endocrinol Metab. 2011;24(3-4):187-9. doi: 10.1515/jpem.2011.083.