Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Future Microbiol. 2020 May;15:649-677. doi: 10.2217/fmb-2019-0333. Epub 2020 Jun 4.
, , , , , spp. and spp. are part of a group of pathogens that pose a major threat to human health due to the emergence of multidrug-resistant strains. Moreover, these bacteria have several virulence factors that allow them to successfully colonize their hosts, such as toxins and the ability to produce biofilms, resulting in an urgent need to develop new strategies to fight these pathogens. In this review, we compile the most up-to-date information on the epidemiology, virulence and resistance of these clinically important microorganisms. Additionally, we address new therapeutic alternatives, with a focus on molecules with antivirulence activity, which are considered promising to combat multidrug-resistant bacteria.
,,,,, spp. 和 spp. 是一组病原体的一部分，由于多药耐药菌株的出现，这些病原体对人类健康构成了重大威胁。此外，这些细菌具有多种毒力因子，使它们能够成功地在宿主中定植，例如毒素和产生生物膜的能力，这导致迫切需要开发新的策略来对抗这些病原体。在这篇综述中，我们汇编了这些临床重要微生物的流行病学、毒力和耐药性的最新信息。此外，我们还讨论了新的治疗选择，重点是具有抗病毒活性的分子，这些分子被认为是对抗多药耐药细菌有希望的。
