Takács L, Szénási G, Bencsáth P
Division of Clinical Immunology, Nephrology and Endocrinology, Joint Research Organization of the Hungarian Academy of Sciences, Budapest.
Acta Med Hung. 1988;45(3-4):365-75.
Earlier contradictory results as to whether renal nerves are necessary for adaptation to a low dietary sodium intake in the rat were ascribed to strain differences or to sympathetic stimulation caused by carbohydrates when changing from a low-sucrose normal-sodium diet to a high-sucrose sodium-deficient diet. In the present work, daily sodium excretion was studied for 4 days before and after bilateral renal denervation or sham operation in three strains of rats (CFY, Wistar, and Long Evans). After ingesting a normal sodium diet containing no sucrose, CFY and Wistar rats were fed a sodium-deficient diet containing 67% sucrose. Long Evans rats were sodium-depleted by feeding them boiled rice. Daily and cumulative sodium excretion and sodium balance were similar in all three groups during 4-day sodium-depletion periods before and after bilateral renal denervation or sham operation. The results suggest that in sodium-depleted rats denervation natriuresis can be ascribed neither to strain differences nor to the high sucrose content of the low-sodium diet.
关于肾神经对大鼠适应低钠饮食是否必要，早期的研究结果相互矛盾，这归因于品系差异，或者是在从低蔗糖正常钠饮食转变为高蔗糖缺钠饮食时，碳水化合物引起的交感神经刺激。在本研究中，对三组大鼠（CFY、Wistar和Long Evans）进行双侧肾去神经支配或假手术后，分别在术前和术后4天研究每日钠排泄情况。在摄入不含蔗糖的正常钠饮食后，给CFY和Wistar大鼠喂食含67%蔗糖的缺钠饮食。通过给Long Evans大鼠喂食米饭使其缺钠。在双侧肾去神经支配或假手术前后的4天缺钠期内，所有三组大鼠的每日和累积钠排泄量以及钠平衡均相似。结果表明，在缺钠大鼠中，去神经利尿既不能归因于品系差异，也不能归因于低钠饮食中的高蔗糖含量。
