Graduate Program of Food Nutrition and Health, Department of Nutrition, Federal University of Bahia, Salvador-Bahia, Brazil.
Academic Center of Vitória de Santo Antão, Federal University of Pernambuco, Recife, Brazil.
Nutr Neurosci. 2022 Mar;25(3):502-510. doi: 10.1080/1028415X.2020.1764291. Epub 2020 Jun 4.
To analyze the effects of exposure to a high-fat diet during the perinatal period and after weaning on white adipose tissue accumulation and gene expression of TNF- α and NF- κB. Wistar female rats were fed with high-fat (H) or control (C) diet during pregnancy and lactation. The offspring were allocated into four groups: Control Control (CC), offspring of mothers GC, fed a control diet after weaning; Control High-fat (CH), offspring of mothers GC, fed a hight-fat diet after weaning; High-fat Control (HC), offspring of mothers GH, fed with control diet after weaning; and High-fat High-fat (HH), offspring of mothers GH, fed a H diet after weaning. HH and HC groups showed increased body weight compared to CC group and increases in caloric intake, larger amount of white adipose tissue and adipocyte size compared to CC and CH groups. The HH and CH groups showed higher NF-kB expression in white adipose tissue compared to the CC and HC groups, and the HH group also showed higher TNF- α expression. In the hypothalamus, the HH and HC groups exhibited higher TNF- α expression compared to the CC and CH groups. Perinatal and post-weaning exposure to the high-fat diet increases the amount of white adipose tissue, adipocyte size, and expression of the inflammatory genes TNF-α and NF-kB.
分析围产期和断奶后暴露于高脂肪饮食对白色脂肪组织积累和 TNF-α和 NF-κB 基因表达的影响。Wistar 雌性大鼠在妊娠期和哺乳期喂食高脂肪（H）或对照（C）饮食。后代分为四组：对照对照（CC），母亲 GC 喂养的后代，断奶后喂食对照饮食；对照高脂肪（CH），母亲 GC 喂养的后代，断奶后喂食高脂肪饮食；高脂肪对照（HC），母亲 GH 喂养的后代，断奶后喂食对照饮食；高脂肪高脂肪（HH），母亲 GH 喂养的后代，断奶后喂食高脂肪饮食。HH 和 HC 组与 CC 组相比，体重增加，与 CC 和 CH 组相比，热量摄入增加，白色脂肪组织和脂肪细胞大小增加。HH 和 CH 组白色脂肪组织中 NF-kB 的表达高于 CC 和 HC 组，HH 组 TNF-α的表达也较高。在下丘脑，HH 和 HC 组 TNF-α的表达高于 CC 和 CH 组。围产期和断奶后暴露于高脂肪饮食会增加白色脂肪组织的数量、脂肪细胞大小以及炎症基因 TNF-α和 NF-κB 的表达。
