Animal Parasitology Department, Veterinary Institute, Federal Rural University of Rio de Janeiro, BR 465, Km 7, 23897-000, Seropédica, RJ, Brazil.
Vet Dermatol. 2020 Oct;31(5):355-e92. doi: 10.1111/vde.12857. Epub 2020 Jun 4.
Lynxacarus radovskyi is a fur mite of cats. Several classes of ectoparasiticides have shown success for treatment, including an isoxazoline.
To evaluate the efficacy of a single oral dose of sarolaner for the treatment of L. radovskyi mites in naturally infested cats.
Fourteen adult cats (six males and eight females), naturally infested with L. radovskyi.
Animals were randomized according to sex and average pretreatment mite count. The cats were assigned to two groups of seven cats each. The treated group received one 10 mg sarolaner tablet, corresponding to a dose of 2-4 mg/kg body weight, and the control group received no treatment. From each cat, three trichograms consisting of approximately 50 hairs each were collected from the dorsal neck, lateral thigh and perineum/tail region (total of nine samples per cat). The severity of infestation was scored on a scale of 0 (no parasites) to 4 (>50 mites) at baseline and days 7, 15, 30, 45 and 60 post-treatment. Efficacy was compared between the treatment and control groups using the arithmetic mean reduction of the mite score; results were analysed using the Kruskal-Wallis test followed by the Student-Newtman-Keuls test, with significance set at P < 5%.
The efficacy of oral sarolaner was >95% at Day 30 post-treatment. Statistical differences were first observed between the means of the control and treated groups 15 days post-treatment.
A single oral dose of sarolaner effectively eliminated L. radovskyi in most cats.
Lynxacarus radovskyi 是一种寄生在猫身上的毛皮螨。几类外寄生虫防治药物已被证明对此类螨的治疗有效，包括异恶唑啉类药物。
评估单次口服萨罗拉纳治疗自然感染 L. radovskyi 螨虫的猫的疗效。
14 只成年猫（6 只雄性和 8 只雌性），自然感染了 L. radovskyi 螨虫。
根据性别和平均预处理螨虫计数对动物进行随机分组。将猫分为两组，每组 7 只。治疗组给予一片 10mg 萨罗拉纳，相当于 2-4mg/kg 体重的剂量，对照组不给予任何治疗。从每只猫的背部颈部、侧大腿和会阴/尾部区域采集三个 Trichogram，每个 Trichogram 包含大约 50 根毛发（每只猫总共 9 个样本）。在基线和治疗后第 7、15、30、45 和 60 天，根据寄生虫严重程度对每个样本进行 0（无寄生虫）至 4（>50 只螨虫）的评分。使用螨评分的算术平均值减少来比较治疗组和对照组之间的疗效；结果使用 Kruskal-Wallis 检验进行分析，然后使用 Student-Newtman-Keuls 检验，显著性水平设为 P < 5%。
口服萨罗拉纳的疗效在治疗后第 30 天>95%。在治疗后第 15 天，首次观察到对照组和治疗组之间的平均值存在统计学差异。
单次口服萨罗拉纳可有效消除大多数猫身上的 L. radovskyi。
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