Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, MD 21250, USA.
Department of Chemical, Biochemical and Environmental Engineering, University of Maryland Baltimore County, MD 21250, USA.
Trends Biotechnol. 2020 Jul;38(7):686-688. doi: 10.1016/j.tibtech.2020.01.008. Epub 2020 Feb 22.
Flavonoids are plant-derived natural products with human health-promoting benefits. The modularity and complexity of the flavonoid biosynthetic pathway allow us to leverage the metabolic characteristics of distinct microbial hosts and install structural functionalities beyond what monocultures can achieve. We discuss the promising future of applying microbial cocultures to improve the cost-efficiency and diversity of flavonoid biosynthesis.
类黄酮是具有促进人类健康益处的植物源性天然产物。类黄酮生物合成途径的模块化和复杂性使我们能够利用不同微生物宿主的代谢特性，并安装超越单一培养物所能实现的结构功能。我们讨论了应用微生物共培养来提高类黄酮生物合成的成本效益和多样性的广阔前景。
