Université de Lyon, VetAgro Sup, APCSe Agressions Pulmonaires et Circulatoires dans le Sepsis, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, Vetagro Sup, Unité de Physiologie, Pharmacodynamie et Thérapeutique, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France.
Université Clermont Auvergne, INRAE, VetAgro Sup, UMR EPIA, Theix, F-63122 Saint-Genès-Champanelle, France; Université de Lyon, INRAE, VetAgro Sup, UMR EPIA, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France; Université de Lyon, INRAE, VetAgro Sup, Usc 1233 UR RS2GP, 1 avenue Bourgelat, F-69280 Marcy l'Etoile, France.
Microvasc Res. 2020 Sep;131:104025. doi: 10.1016/j.mvr.2020.104025. Epub 2020 Jun 1.
The aims of the study were to evaluate the influence of hemodynamic status on pressure artifacts and the impact of pressure artifacts on microcirculatory flow.
Sublingual microcirculation was assessed using a Sidestream Dark Field handheld imaging device in 7 anesthetized piglets, submitted to pharmacologically-induced blood pressure variations. For each video, a pressure score of 0, 1, or 10 was assigned for the category "pressure artifacts" of the "microcirculation image quality score". Videos with a pressure score of 0 and 1 were considered as "passing videos". The videos with a score of 10 were considered as "failing videos". Multivariate logistic regression models and multivariate linear mixed models with individual random effects were used.
As blood pressure decreased, the probability of obtaining a "failing video" increased (P = 0.0008). Pressure scores of 10 influenced significantly the perfused De Backer score (small and all vessels), the proportion of perfused vessels (small and all vessels), the microvascular flow index and the heterogeneity index. Pressure scores of 1 influenced significantly the parameters above-mentioned, except the perfused De Backer score for all vessels.
The probability of obtaining pressure artifacts during recording of microcirculation videos was higher when the arterial pressure was low. The presence of acceptable pressure artifacts also influenced microcirculation analysis.
本研究旨在评估血流动力学状态对压力伪影的影响，以及压力伪影对微循环血流的影响。
在 7 只麻醉猪中使用 Sidestream Dark Field 手持式成像设备评估舌下微循环，这些猪接受了药理学诱导的血压变化。对于每个视频，根据“微循环图像质量评分”中的“压力伪影”类别，分配 0、1 或 10 的压力评分。压力评分为 0 和 1 的视频被认为是“合格视频”。评分 10 的视频被认为是“不合格视频”。使用多变量逻辑回归模型和具有个体随机效应的多变量线性混合模型。
随着血压下降，获得“不合格视频”的概率增加（P=0.0008）。压力评分为 10 显著影响灌注 De Backer 评分（小血管和所有血管）、灌注血管比例（小血管和所有血管）、微血管血流指数和异质性指数。压力评分为 1 显著影响上述参数，除了所有血管的灌注 De Backer 评分。
在记录微循环视频时，当动脉压较低时，获得压力伪影的概率更高。可接受的压力伪影的存在也会影响微循环分析。
